Alsouhibani Ali, Hoeger Bement Marie
Clinical & Translational Rehabilitation Health Science Program, Department of Physical Therapy, College of Health Sciences, Marquette University, Milwaukee, WI, USA.
Department of Physical Therapy, College of Medical Rehabilitation, Qassim University, Buraydah, Saudi Arabia.
Pain Rep. 2022 Apr 1;7(3):e996. doi: 10.1097/PR9.0000000000000996. eCollection 2022 May-Jun.
Exercise is an effective nonpharmacological intervention for individuals with fibromyalgia syndrome (FMS); however, considerable variability is observed in their pain response after a single exercise session that could be due to differences in baseline central pain inhibition (ie, conditioned pain modulation [CPM]).
This study examined the effect of isometric exercise on CPM in people with FMS and control participants. A subaim was to identify whether pain inhibition after exercise was due to differences in baseline CPM.
Twenty-one individuals with FMS (50.5 ± 14.9 years) and 22 age-matched and sex-matched controls (49.2 ± 13.3 years) participated in a familiarization session and 2 randomized experimental sessions: (1) low-intensity isometric exercise and (2) quiet rest control. Conditioned pain modulation was measured before and after each experimental session. In addition, body composition and physical activity levels were collected to determine potential group differences.
Both groups had comparable body composition and physical activity levels and reported similar exercise-induced hypoalgesia (increase in pressure pain thresholds) at the exercising muscle (quadriceps muscle) and systemically (deltoid muscle). Both groups had a decrease in CPM after exercise and quiet rest; however, in both FMS and control participants with impaired baseline CPM, there was an increase in CPM at the deltoid muscle after exercise.
In persons with low CPM, irrespective of health status, isometric exercise enhanced CPM at a site distal from the exercising muscle. Our results support the use of isometric exercise when initiating an exercise program especially for individuals with impaired CPM.
运动是纤维肌痛综合征（FMS）患者有效的非药物干预措施；然而，单次运动后其疼痛反应存在相当大的变异性，这可能是由于基线中枢性疼痛抑制（即条件性疼痛调制[CPM]）的差异所致。
本研究探讨等长运动对FMS患者和对照参与者CPM的影响。一个次要目的是确定运动后疼痛抑制是否归因于基线CPM的差异。
21名FMS患者（50.5±14.9岁）和22名年龄及性别匹配的对照者（49.2±13.3岁）参加了一次熟悉训练和2次随机实验训练：（1）低强度等长运动和（2）安静休息对照。在每次实验训练前后测量条件性疼痛调制。此外，收集身体成分和身体活动水平以确定潜在的组间差异。
两组的身体成分和身体活动水平相当，并且在运动肌肉（股四头肌）和全身（三角肌）报告了相似的运动诱导性痛觉减退（压力痛阈值增加）。运动和安静休息后两组的CPM均降低；然而，在基线CPM受损的FMS患者和对照参与者中，运动后三角肌的CPM均增加。
在CPM较低的人群中，无论健康状况如何，等长运动均可增强运动肌肉远端部位的CPM。我们的结果支持在启动运动计划时使用等长运动，特别是对于CPM受损的个体。
