Busarira Musa O, Getlawi Omaima H, Hawda Salima M, Falgosh Salha A, Peela Jagannadha Rao
Department of Obstetrics and Gynaecology, Faculty of medicine, Benghazi University, Benghazi, Libya.
Department of Biochemistry, Faculty of medicine, Benghazi University, Benghazi, Libya.
J Pharm Bioallied Sci. 2021 Oct-Dec;13(4):394-400. doi: 10.4103/jpbs.jpbs_168_21. Epub 2022 Mar 4.
The aim of this study was the comparison of the glycemic control and maternal outcomes in women affected with gestational diabetes mellitus (GDM) managed with metformin versus insulin.
The participants included in this study were 140 women diagnosed with GDM. They were randomized into two groups, women included in the first group were treated with metformin and the women of the second group were managed with insulin.
The glycemic control was similar in both the treatment arms and the only noteworthy difference was found in the mean fasting blood glucose, which was significantly higher in the women receiving insulin as compared to the women receiving metformin. There were no substantial differences in the maternal outcome with the use of metformin compared to insulin in women with GDM.
The incidence of operative delivery was higher in metformin-treated group, whereas the hospital admission rate was considerably elevated in insulin-treated group.
本研究的目的是比较用二甲双胍与胰岛素治疗的妊娠期糖尿病（GDM）女性的血糖控制情况及母体结局。
本研究的参与者为140名被诊断为GDM的女性。她们被随机分为两组，第一组女性接受二甲双胍治疗，第二组女性接受胰岛素治疗。
两个治疗组的血糖控制情况相似，唯一值得注意的差异在于平均空腹血糖，接受胰岛素治疗的女性的平均空腹血糖显著高于接受二甲双胍治疗的女性。在GDM女性中，使用二甲双胍与使用胰岛素相比，母体结局没有实质性差异。
二甲双胍治疗组的手术分娩发生率较高，而胰岛素治疗组的住院率显著升高。
