环丝氨酸在中国骨关节结核患者中的骨穿透情况。
Bone Penetration of Cycloserine in Osteoarticular Tuberculosis Patients of China.
机构信息
National Clinical Laboratory on Tuberculosis, Beijing Key Laboratory for Drug-Resistant Tuberculosis Research, Beijing Chest Hospitalgrid.414341.7, Capital Medical University, Beijing Tuberculosis and Thoracic Tumor Institute, Beijing, China.
Department of Orthopedics, Beijing Chest Hospitalgrid.414341.7, Capital Medical University, Beijing, China.
出版信息
Antimicrob Agents Chemother. 2022 May 17;66(5):e0222421. doi: 10.1128/aac.02224-21. Epub 2022 Apr 11.
The cycloserine concentrations in plasma and bone that were collected during operations on 28 osteoarticular tuberculosis (TB) patients treated daily with a 500-mg cycloserine-containing regimen were determined. The median concentrations in plasma and bone were 16.29 μg/mL (interquartile range [IQR], 6.47 μg/mL) and 24.33 μg/g (IQR, 14.68 μg/g), respectively. The median bone/plasma penetration ratio was 0.76 (range, 0.33 to 1.98). Cycloserine could effectively penetrate bone and acquire concentrations comparable to those in plasma, which favors its usage in osteoarticular TB treatment.
检测了 28 例接受每日 500mg 环丝氨酸方案治疗的骨关节结核（TB）患者手术期间采集的血浆和骨中环丝氨酸浓度。血浆和骨中的中位数浓度分别为 16.29μg/mL（四分位距 [IQR]，6.47μg/mL）和 24.33μg/g（IQR，14.68μg/g）。中位数骨/血浆穿透率为 0.76（范围，0.33 至 1.98）。环丝氨酸可有效穿透骨骼并获得与血浆中相当的浓度，这有利于其在骨关节 TB 治疗中的应用。
Zotero 插件