• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Stress as a Potential Regulatory Factor in the Outcome of Pharmacotherapy.

作者信息

Konstandi Maria, Johnson Elizabeth O, Lang Matti A

机构信息

Department of Pharmacology, Faculty of Medicine, University of Ioannina, Ioannina, Greece.

Department of Anatomy, School of Medicine, European University Cyprus, Nicosia, Cyprus.

出版信息

Front Neurosci. 2022 Mar 23;16:737716. doi: 10.3389/fnins.2022.737716. eCollection 2022.

DOI:10.3389/fnins.2022.737716
PMID:35401076
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8984175/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ce1/8984175/b7f3a8fce720/fnins-16-737716-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ce1/8984175/b7f3a8fce720/fnins-16-737716-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8ce1/8984175/b7f3a8fce720/fnins-16-737716-g0001.jpg

相似文献

1
Stress as a Potential Regulatory Factor in the Outcome of Pharmacotherapy.压力作为药物治疗结果的潜在调节因素。
Front Neurosci. 2022 Mar 23;16:737716. doi: 10.3389/fnins.2022.737716. eCollection 2022.
2
Involvement of CYP3A4, CYP2C8, and CYP2D6 in the metabolism of (R)- and (S)-methadone in vitro.CYP3A4、CYP2C8和CYP2D6在体外对（R）-和（S）-美沙酮代谢中的作用。
Drug Metab Dispos. 2003 Jun;31(6):742-7. doi: 10.1124/dmd.31.6.742.
3
Cytochrome b5 is a major determinant of human cytochrome P450 CYP2D6 and CYP3A4 activity in vivo.细胞色素b5是体内人类细胞色素P450 CYP2D6和CYP3A4活性的主要决定因素。
Mol Pharmacol. 2015 Apr;87(4):733-9. doi: 10.1124/mol.114.097394. Epub 2015 Feb 5.
4
CYP3A4 and CYP2D6 inhibitory activities of Indonesian medicinal plants.印度尼西亚药用植物的CYP3A4和CYP2D6抑制活性。
Phytomedicine. 2006 Jan;13(1-2):67-73. doi: 10.1016/j.phymed.2004.06.022. Epub 2005 Jun 29.
5
Cytochrome P450 expression and regulation in CYP3A4/CYP2D6 double transgenic humanized mice.细胞色素P450在CYP3A4/CYP2D6双转基因人源化小鼠中的表达与调控
Drug Metab Dispos. 2008 Feb;36(2):435-41. doi: 10.1124/dmd.107.018838. Epub 2007 Nov 29.
6
Marsdenia tenacissima extract inhibits gefitinib metabolism in vitro by interfering with human hepatic CYP3A4 and CYP2D6 enzymes.密花紫玉盘提取物通过干扰人肝 CYP3A4 和 CYP2D6 酶来抑制体外吉非替尼的代谢。
J Ethnopharmacol. 2014;151(1):210-7. doi: 10.1016/j.jep.2013.10.021. Epub 2013 Oct 21.
7
Risk assessment of accidental nortriptyline poisoning: the importance of cytochrome P450 for nortriptyline elimination investigated using a population-based pharmacokinetic simulator.意外使用去甲替林导致中毒的风险评估：应用基于人群的药代动力学模拟研究细胞色素 P450 对去甲替林消除的重要性。
Eur J Pharm Sci. 2011 Oct 9;44(3):265-72. doi: 10.1016/j.ejps.2011.08.003. Epub 2011 Aug 11.
8
Identification of CYP3A4 as the primary cytochrome P450 responsible for the metabolism of tandospirone by human liver microsomes.鉴定CYP3A4是人类肝微粒体中负责坦度螺酮代谢的主要细胞色素P450。
Eur J Drug Metab Pharmacokinet. 2007 Jul-Sep;32(3):131-7. doi: 10.1007/BF03190475.
9
Screening of drug metabolizing enzymes for fusidic acid and its interactions with isoform-selective substrates in vitro.夫西地酸药物代谢酶的体外筛选及其与同工酶选择性底物的相互作用
Xenobiotica. 2017 Sep;47(9):778-784. doi: 10.1080/00498254.2016.1230795. Epub 2016 Nov 15.
10
Identification of CYP3A4 as the primary cytochrome P450 responsible for the metabolism of tandospirone by human liver microsomes.鉴定CYP3A4是人类肝微粒体中负责坦度螺酮代谢的主要细胞色素P450。
Eur J Drug Metab Pharmacokinet. 2007 Oct-Dec;32(4):233-40. doi: 10.1007/BF03191009.

引用本文的文献

1
Chronic stress: a fourth etiology in tumorigenesis?慢性应激：肿瘤发生的第四种病因？
Mol Cancer. 2025 Jul 17;24(1):196. doi: 10.1186/s12943-025-02402-x.
2
Rapid Metabolism Underlying Subtherapeutic Serum Levels of Atypical Antipsychotics Preceding Clozapine Treatment: A Retrospective Analysis of Real-World Data.快速代谢导致非典型抗精神病药治疗前出现低于治疗水平的血清浓度：真实世界数据的回顾性分析。
CNS Drugs. 2024 Jun;38(6):473-480. doi: 10.1007/s40263-024-01079-y. Epub 2024 Apr 18.
3
Age-related modifications in CYP-dependent drug metabolism: role of stress.

本文引用的文献

1
Sex steroid hormones differentially regulate CYP2D in female wild-type and CYP2D6-humanized mice.性激素激素在雌性野生型和 CYP2D6 人源化小鼠中差异调节 CYP2D。
J Endocrinol. 2020 May;245(2):301-314. doi: 10.1530/JOE-19-0561.
2
Cytochrome P450 2D6 and Parkinson's Disease: Polymorphism, Metabolic Role, Risk and Protection.细胞色素 P450 2D6 与帕金森病：多态性、代谢作用、风险与保护。
Neurochem Res. 2017 Dec;42(12):3353-3361. doi: 10.1007/s11064-017-2384-8. Epub 2017 Sep 4.
3
Consequences of psychophysiological stress on cytochrome P450-catalyzed drug metabolism.
与年龄相关的 CYP 依赖性药物代谢的改变：应激的作用。
Front Endocrinol (Lausanne). 2023 May 24;14:1143835. doi: 10.3389/fendo.2023.1143835. eCollection 2023.
4
Current Knowledge and Novel Therapeutic Approaches Based on Pharmacokinetics and Pharmacodynamics in Stress-Induced Pathology.基于应激相关病理的药代动力学和药效学的现有知识和新治疗方法。
Medicina (Kaunas). 2022 Jun 22;58(7):839. doi: 10.3390/medicina58070839.
心理生理应激对细胞色素P450催化的药物代谢的影响。
Neurosci Biobehav Rev. 2014 Sep;45:149-67. doi: 10.1016/j.neubiorev.2014.05.011. Epub 2014 May 27.
4
Role of brain cytochrome P450 (CYP2D) in the metabolism of monoaminergic neurotransmitters.脑细胞色素 P450（CYP2D）在单胺类神经递质代谢中的作用。
Pharmacol Rep. 2013;65(6):1519-28. doi: 10.1016/s1734-1140(13)71513-5.
5
Sources of interindividual variability.个体间变异性的来源。
Methods Mol Biol. 2014;1113:363-415. doi: 10.1007/978-1-62703-758-7_17.
6
The endogenous substrates of brain CYP2D.脑CYP2D的内源性底物。
Eur J Pharmacol. 2014 Feb 5;724:211-8. doi: 10.1016/j.ejphar.2013.12.025. Epub 2013 Dec 24.
7
Psychophysiological stress: a significant parameter in drug pharmacokinetics.心理生理学应激：药物药代动力学的重要参数。
Expert Opin Drug Metab Toxicol. 2013 Oct;9(10):1317-34. doi: 10.1517/17425255.2013.816283. Epub 2013 Jul 9.
8
Sex steroid hormones regulate constitutive expression of Cyp2e1 in female mouse liver.性激素调节雌性小鼠肝脏中 Cyp2e1 的组成型表达。
Am J Physiol Endocrinol Metab. 2013 May 15;304(10):E1118-28. doi: 10.1152/ajpendo.00585.2012. Epub 2013 Apr 2.
9
Early maternal deprivation-induced modifications in the neurobiological, neurochemical and behavioral profile of adult rats.早期母婴分离诱导成年大鼠神经生物学、神经化学和行为特征的改变。
Behav Brain Res. 2013 May 1;244:29-37. doi: 10.1016/j.bbr.2013.01.040. Epub 2013 Feb 6.
10
Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation.细胞色素 P450 酶在药物代谢中的作用：基因表达调控、酶活性及遗传变异的影响。
Pharmacol Ther. 2013 Apr;138(1):103-41. doi: 10.1016/j.pharmthera.2012.12.007. Epub 2013 Jan 16.