Yuan Jun-Jian, Xu Yan-Dong, Li Heng, Guo Qing-Jin, Li Guo-Ce, Chai Wei, Zhang Zhi-Quan, Liu Ru-Hai
Department of Hepatobiliary Pancreatic Surgery, Cangzhou Central Hospital, Cangzhou, China.
Department of General Surgery, Renqiu Second People's Hospital, Renqiu, China.
J Oncol. 2022 Mar 30;2022:1192368. doi: 10.1155/2022/1192368. eCollection 2022.
To investigate the combined application value of magnetic resonance imaging (MRI) combined with serum alpha-fetoprotein (AFP)-L3 and Golgi protein (GP)-73 in the diagnosis of primary liver cancer.
The data of 200 patients with suspected liver cancer admitted to our hospital from February 2020 to February 2021 were retrospectively analyzed, and they were randomly divided into an experimental group and a control group, with 100 cases in each group. The experimental group received a combined detection of MRI with serum AFP-L3 and GP-73, and the control group adopted traditional diagnostic methods (spiral computed tomography and serum AFP). The diagnostic yields of the two groups were compared. Surgical resection was performed after the diagnosis of primary liver cancer, and the correlation between the efficacy and combined detection of MRI with serum AFP-L3 and GP-73 levels was analyzed.
The two groups presented comparable general information ( >0.05). The surgical results showed 160 cases of primary liver cancer, including 75 cases in the experimental group and 85 cases in the control group, and 40 cases of benign liver lesions. The diagnostic accuracy of the experimental group (73/75, 95%) was significantly higher than that of the control group (76/85, 86%) ( < 0.05). The serum levels of AFP-L3, GP-73, and AFP in patients with primary liver cancer were remarkably decreased after surgery ( < 0.001). The preoperative and postoperative AFP-L3, GP-73, and AFP levels of patients with primary liver cancer were significantly higher than those of patients with benign liver lesions. The AUC (95% CI) for the combined detection of MRI and serum AFP-L3 and GP-73 levels in patients with surgically confirmed primary liver cancer was 0.747 (0.619-0.874).
MRI combined with serum AFP-L3 and GP-73 presents favorable diagnostic efficiency in the diagnosis of primary liver cancer, which is worthy of clinical application.
探讨磁共振成像（MRI）联合血清甲胎蛋白异质体（AFP）-L3和高尔基体蛋白（GP）-73在原发性肝癌诊断中的联合应用价值。
回顾性分析2020年2月至2021年2月我院收治的200例疑似肝癌患者的数据，将其随机分为实验组和对照组，每组100例。实验组采用MRI联合血清AFP-L3和GP-73进行联合检测，对照组采用传统诊断方法（螺旋计算机断层扫描和血清AFP）。比较两组的诊断率。确诊原发性肝癌后进行手术切除，分析疗效与MRI联合血清AFP-L3和GP-73水平检测之间的相关性。
两组一般资料具有可比性（>0.05）。手术结果显示原发性肝癌160例，其中实验组75例，对照组85例，良性肝病变40例。实验组的诊断准确率（73/75，95%）显著高于对照组（76/85，86%）（<0.05）。原发性肝癌患者术后血清AFP-L3、GP-73和AFP水平显著降低（<0.001）。原发性肝癌患者术前和术后的AFP-L3、GP-73和AFP水平显著高于良性肝病变患者。手术确诊的原发性肝癌患者中，MRI联合血清AFP-L3和GP-73水平检测的曲线下面积（AUC，95%CI）为0.747（0.619 - 0.874）。
MRI联合血清AFP-L3和GP-73在原发性肝癌诊断中具有良好的诊断效率，值得临床应用。
