Badat Ahmed, Lowton Karishma
Department of Psychiatry, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
S Afr J Psychiatr. 2022 Mar 29;28:1782. doi: 10.4102/sajpsychiatry.v28i0.1782. eCollection 2022.
Although reports of neuropsychiatric side effects have been reported with efavirenz, these have been limited in comparison with regard to the now recommended dolutegravir regimens. We present a patient with new onset neuropsychiatric manifestations secondary to dolutegravir that resulted in significant physical injuries. The patient was initiated on risperidone for symptomatic control which was subsequently weaned and discontinued following reverting to an original efavirenz antiretroviral regimen, with resolution of neuropsychiatric symptoms. Neuropsychiatric side effects are increasingly noted with dolutegravir, and these should be monitored for on initiation and switching of treatment regimens.
尽管已有依非韦伦导致神经精神副作用的报道，但与目前推荐的多替拉韦方案相比，这些报道较为有限。我们报告了一名患者，其因多替拉韦继发新发性神经精神症状，导致了严重身体损伤。该患者开始使用利培酮进行症状控制，随后在恢复原来的依非韦伦抗逆转录病毒方案后逐渐减停，神经精神症状得以缓解。多替拉韦导致的神经精神副作用越来越受到关注，在开始和更换治疗方案时应进行监测。
