Cuevas Heather, Danesh Valerie, Henneghan Ashley
School of Nursing, University of Texas at Austin, 1710 Red River St. Mail Code D0100, Austin 78712, TX, USA.
Center for Applied Health Research, Baylor Scott & White Research Institute, 2401 S. 31st St Temple, Dallas 76508, TX, USA.
J Aging Res. 2022 Mar 31;2022:5803337. doi: 10.1155/2022/5803337. eCollection 2022.
Globally, one in three adults has a chronic condition. Many chronic diseases that are not neurological in nature (e.g., diabetes and heart failure) are increasingly associated with cognitive symptoms. However, the instruments used to assess cognitive symptoms in those with nonneurologic chronic illness are heterogeneous, and questions remain as to how cognitive symptoms may be related to demographic and clinical outcome variables, neurocognitive test performance, and other patient-reported outcomes. In this review, we describe associations among self-reported cognitive function, cognitive performance, and additional patient-reported outcomes as well as how cognitive symptoms are measured in nonneurologic chronic illness.
Multiple databases (PubMed, Medline, CINAHL, PsycInfo, EMBASE, SCOPUS, the Cochrane Library, and Academic Search Complete) were searched for studies from 1990 to 2020 that provided data on self-reported cognitive symptoms in those with nonneurological chronic conditions. Initial search yielded 304 articles, of which 32 met inclusion criteria. Quality assessment was conducted using the Critical Appraisal Skills Programme.
Thirty-two total studies were included: twenty cross-sectional, 10 longitudinal, and 2 randomized controlled trials. The tools used to assess self-reported cognitive function in the studies were heterogeneous: 28 unique tools were used. Thirty studies examined associations among self-reported cognitive function and other patient-reported outcomes. In 19 there were significant associations. Six studies showed no significant associations between neuropsychological tests and self-reported cognitive function; another 6 studies found a significant association.
Tools to assess cognitive symptoms were heterogeneous. In most studies, self-reported cognitive symptoms were not correlated with neuropsychological test results, but the majority of studies found a strong association between self-reported cognitive function and other patient-reported outcomes. . Consensus on measuring cognitive symptoms would facilitate cross-study comparisons and facilitate scientific progress in those with nonneurological chronic conditions. Based on these results, there is a need to establish a standardized approach for self-reported cognitive function measurement in patients with nonneurologic chronic illness.
在全球范围内，三分之一的成年人患有慢性病。许多非神经性质的慢性疾病（如糖尿病和心力衰竭）越来越多地与认知症状相关。然而，用于评估非神经慢性疾病患者认知症状的工具多种多样，认知症状如何与人口统计学和临床结局变量、神经认知测试表现以及其他患者报告的结局相关，仍存在疑问。在本综述中，我们描述了自我报告的认知功能、认知表现与其他患者报告的结局之间的关联，以及在非神经慢性疾病中如何测量认知症状。
检索多个数据库（PubMed、Medline、CINAHL、PsycInfo、EMBASE、SCOPUS、Cochrane图书馆和学术搜索完整版），查找1990年至2020年提供非神经慢性疾病患者自我报告认知症状数据的研究。初步检索得到304篇文章，其中32篇符合纳入标准。使用批判性评估技能计划进行质量评估。
共纳入32项研究：20项横断面研究、10项纵向研究和2项随机对照试验。研究中用于评估自我报告认知功能的工具多种多样：使用了28种独特的工具。30项研究探讨了自我报告的认知功能与其他患者报告的结局之间的关联。其中19项存在显著关联。6项研究表明神经心理学测试与自我报告的认知功能之间无显著关联；另外6项研究发现存在显著关联。
评估认知症状的工具多种多样。在大多数研究中，自我报告的认知症状与神经心理学测试结果不相关，但大多数研究发现自我报告的认知功能与其他患者报告的结局之间存在密切关联。就认知症状测量达成共识将有助于跨研究比较，并促进非神经慢性疾病患者的科学进展。基于这些结果，有必要为非神经慢性疾病患者自我报告认知功能测量建立标准化方法。
