Kobayashi Takako, Isohashi Fumiaki, Eino Daisuke, Tanaka Kazunori, Sawada Kenjiro, Ueda Yutaka, Kobayashi Eiji, Tomimatsu Takuji, Kimura Tadashi, Ogawa Kazuhiko
Department of Radiation Oncology, Osaka University Graduate School of Medicine, Suita, Japan.
Department of Gynecology and Obstetrics, Osaka University Graduate School of Medicine, Suita, Japan.
Cancer Diagn Progn. 2021 Jul 3;1(4):331-337. doi: 10.21873/cdp.10044. eCollection 2021 Sep-Oct.
BACKGROUND/AIM: This study aimed to evaluate the association between the change in peripheral eosinophil count during postoperative pelvic radiotherapy and gastrointestinal (GI) toxicities in patients with cervical cancer.
The medical records of 163 patients with cervical cancer who underwent postoperative concurrent chemoradiotherapy between 2000 and 2016 were analyzed.
Among the peripheral blood cell counts, transient elevation of the eosinophil count was observed during radiotherapy. Of the 163 patients, 117 developed grade ≥2 diarrhea during radiotherapy, and 25 patients developed grade ≥2 late GI toxicities. In multivariate analysis, the maximum eosinophil count and age emerged as independent predictors of grade ≥2 acute diarrhea during radiotherapy, while bowel bag V and age were predictive of grade ≥2 late GI toxicities.
Early detection of transient elevation of eosinophil may facilitate early treatment of acute diarrhea during radiotherapy.
背景/目的：本研究旨在评估宫颈癌患者术后盆腔放疗期间外周血嗜酸性粒细胞计数变化与胃肠道（GI）毒性之间的关联。
分析了2000年至2016年间接受术后同步放化疗的163例宫颈癌患者的病历。
在外周血细胞计数中，放疗期间观察到嗜酸性粒细胞计数短暂升高。163例患者中，117例在放疗期间出现≥2级腹泻，25例出现≥2级晚期胃肠道毒性。多因素分析显示，放疗期间嗜酸性粒细胞计数最高值和年龄是≥2级急性腹泻的独立预测因素，而肠袋容积V和年龄是≥2级晚期胃肠道毒性的预测因素。
早期发现嗜酸性粒细胞短暂升高可能有助于放疗期间急性腹泻的早期治疗。
