PEA15的高表达与恶性胸膜间皮瘤患者的生存率相关。
High Expression of PEA15 Is Associated With Patient Survival in Malignant Pleural Mesothelioma.
作者信息
Islam Shajedul, Kitagawa Takao, Kuramitsu Yasuhiro
机构信息
Advanced Research Promotion Center, Health Sciences University of Hokkaido, Hokkaido, Japan.
Oral Health Science Center, Tokyo Dental College, Tokyo, Japan.
出版信息
Cancer Diagn Progn. 2021 Jul 3;1(4):371-377. doi: 10.21873/cdp.10049. eCollection 2021 Sep-Oct.
BACKGROUND/AIM: Malignant pleural mesothelioma (MPM) is a rare but very aggressive tumor that is primarily pleural in origin. The 5-year overall survival rate of patients with MPM has not improved despite therapeutic advances. Therefore, biomarker discovery to identify premalignant or early malignant tumors of the mesothelium are crucial. PEA15 is a cytoplasmic protein that is involved in various human malignancies, including MPM. However, the clinicopathological involvement of PEA15 in MPM has not yet been documented.
MATERIALS AND METHODS
The Oncomine database and GEPIA2 platform were used to analyze PEA15 mRNA expression and patient survival in patients with MPM.
RESULTS
PEA15 was found to be significantly up-regulated in MPM, and this up-regulation inversely correlated with prolonged patient survival. Further, PEA15 expression was found to be increased in other cancer tissues without affecting overall survival.
CONCLUSION
PEA15 may represent a new potential prognostic biomarker in MPM patients.
背景/目的：恶性胸膜间皮瘤（MPM）是一种罕见但极具侵袭性的肿瘤，主要起源于胸膜。尽管治疗取得了进展，但MPM患者的5年总生存率并未提高。因此，发现用于识别间皮瘤癌前或早期恶性肿瘤的生物标志物至关重要。PEA15是一种细胞质蛋白，参与包括MPM在内的多种人类恶性肿瘤。然而，PEA15在MPM中的临床病理相关性尚未见报道。
材料与方法
使用Oncomine数据库和GEPIA2平台分析MPM患者中PEA15 mRNA表达和患者生存情况。
结果
发现PEA15在MPM中显著上调，且这种上调与患者生存期延长呈负相关。此外，发现PEA15在其他癌组织中表达增加，但不影响总生存期。
结论
PEA15可能是MPM患者一种新的潜在预后生物标志物。
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