Apaydin Arikan Evsen, Aydemir Levent, Ulusan Murat, Yilmazbayhan Dilek, Ozluk Yasemin
Department of Pathology, Istanbul Faculty of Medicine, 64041Istanbul University, Istanbul, Turkey.
Department of Otorhinolaryngology and Head and Neck Surgery, Istanbul Faculty of Medicine, 64041Istanbul University, Istanbul, Turkey.
Int J Surg Pathol. 2023 Apr;31(2):124-136. doi: 10.1177/10668969221091590. Epub 2022 Apr 11.
. The sinonasal tract is the second most common site of human papillomavirus (HPV)-related carcinomas in the head and neck. Published data on the association between sinonasal tumors and HPV are quite inconsistent among different regions. . We performed high-risk HPV DNA in situ hybridization (ISH) and p16 immunohistochemistry on sinonasal carcinomas diagnosed between 2006 and 2016. . Of 105 sinonasal carcinomas, we found only two (2%) HPV-positive cases; both had non-keratinizing morphology and were diffusely positive for p16. By histologic type, HPV DNA positivity rate was 14% in non-keratinizing squamous cell carcinomas, and we did not detect HPV DNA in any other type of sinonasal carcinomas. Thirteen HPV-negative tumors (7 salivary gland carcinomas, 3 sinonasal undifferentiated carcinomas, 2 keratinizing squamous cell carcinomas, and 1 non-keratinizing squamous cell carcinoma) were positive for p16. In nine carcinomas arising from an underlying sinonasal papilloma, p16 and HPV DNA ISH were evaluated in both carcinoma and papilloma areas and all were negative. Follow-up information was available for 104 patients; 46 (44%) were alive and 58 (55%) died of disease. One of the two HPV-positive patients died of the disease; the other was alive at 100 months of follow-up. . We detected a much lower percentage of HPV positivity in sinonasal carcinomas when compared to the literature. We believe that our results support various rates of HPV-related carcinomas depending on the geographic and ethnic characteristics.
鼻窦是头颈部人乳头瘤病毒（HPV）相关癌的第二常见部位。不同地区关于鼻窦肿瘤与HPV之间关联的已发表数据差异很大。我们对2006年至2016年间诊断的鼻窦癌进行了高危型HPV DNA原位杂交（ISH）和p16免疫组化检测。在105例鼻窦癌中，我们仅发现2例（2%）HPV阳性病例；两者均为非角化形态，且p16弥漫阳性。按组织学类型，非角化鳞状细胞癌的HPV DNA阳性率为14%，而在其他类型的鼻窦癌中未检测到HPV DNA。13例HPV阴性肿瘤（7例涎腺癌、3例鼻窦未分化癌、2例角化鳞状细胞癌和1例非角化鳞状细胞癌）p16呈阳性。在9例由潜在鼻窦乳头状瘤发生的癌中，对癌组织和乳头状瘤组织区域均进行了p16和HPV DNA ISH检测，结果均为阴性。有104例患者的随访信息；46例（44%）存活，58例（55%）死于疾病。2例HPV阳性患者中有1例死于该疾病；另一例在随访100个月时仍存活。与文献相比，我们在鼻窦癌中检测到的HPV阳性率要低得多。我们认为，我们的结果支持根据地理和种族特征存在不同比例的HPV相关癌。
