Department of Neonatology, Cangzhou Central Hospital, Cangzhou, Hebei, China.
Clin Hemorheol Microcirc. 2022;81(4):281-291. doi: 10.3233/CH-221388.
Scoring neonatal acute physiology is significant for improving the survival rate of neonates in neonatal intensive care units (NICU). Red blood cell distribution width to platelet ratio (RPR) has been used to evaluate physiology of multiple diseases. However, the value of RPR as a predictor for morbidity and mortality in NICU remains unclear. The score for neonatal acute physiology and perinatal extension II (SNAPE-II) was used to evaluate the physiology and separate neonates into Mild (n = 45), Moderate (n = 45) and Severe (n = 45) groups. White blood cell count (WBC), procalcitonin (PCT) and C-reactive protein (CRP) in cord blood were examine. Spearman's correlation and receiver operating characteristic analysis were performed to demonstrated the correlations of these indicators. There was a positive correlation between the SNAPE-II scores and RPR in neonates in NICU. The WBC, PCT and CRP levels increased with the upregulation of SNAPE-II scores in neonates in NICU and there were positive correlations between RPR and WBC, PCT and CRP, respectively. RPR could be used as a supplementary predictor for the evaluation of neonatal morbidity and mortality in NICU beside SNAPE-II.
评分新生儿急性生理学对提高新生儿重症监护病房（NICU）新生儿的存活率具有重要意义。红细胞分布宽度与血小板比值（RPR）已被用于评估多种疾病的生理状况。然而，RPR 作为 NICU 发病率和死亡率预测因子的价值尚不清楚。使用新生儿急性生理学和围产期扩展 II 评分（SNAPE-II）来评估生理学，并将新生儿分为轻度（n=45）、中度（n=45）和重度（n=45）组。检测脐带血中的白细胞计数（WBC）、降钙素原（PCT）和 C 反应蛋白（CRP）。采用 Spearman 相关分析和受试者工作特征分析来证明这些指标之间的相关性。NICU 中新生儿的 SNAPE-II 评分与 RPR 呈正相关。NICU 中新生儿的 SNAPE-II 评分升高，WBC、PCT 和 CRP 水平也随之升高，RPR 与 WBC、PCT 和 CRP 之间分别呈正相关。除 SNAPE-II 外，RPR 可作为评估 NICU 新生儿发病率和死亡率的补充预测因子。
