电化学吲哚脱芳构化：构建多样含氟螺环吲哚啉。
Electrochemical Dearomatization of Indoles: Access to Diversified Fluorine-Containing Spirocyclic Indolines.
机构信息
Institute of Drug Discovery Technology, Ningbo University, 315211 Ningbo, Zhejiang, China.
Qian Xuesen Collaborative Research Center of Astrochemistry and Space Life Sciences, Ningbo University, 315211 Ningbo, Zhejiang, China.
出版信息
Org Lett. 2022 Apr 22;24(15):2788-2792. doi: 10.1021/acs.orglett.2c00530. Epub 2022 Apr 11.
PMID:35404622
Abstract
A robust and green electrochemical dearomatization of indoles was developed by merging a fluorine-containing group to an indole nucleus under oxidant-free conditions, delivering a diverse array of tri- and difluoromethylated 3,3-spiroindolines with good functional group tolerance.
摘要
发展了一种在无氧化剂条件下通过在吲哚核中引入含氟基团来实现吲哚的电化学脱芳构化的方法，该方法具有较强的实用性和绿色性，能以良好的官能团耐受性得到一系列多样的三氟甲基和二氟甲基取代的 3,3-螺吲哚啉化合物。
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