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Challenges and Gaps in Clinical Trial Genomic Data Management.

作者信息

Asad Sarah, Kananen Kathryn, Mueller Kurt R, Symmans W Fraser, Wen Yujia, Perou Charles M, Blachly James S, Chen James, Vincent Benjamin G, Stover Daniel G

机构信息

Ohio State University Comprehensive Cancer Center, Columbus, OH.

University of Texas MD Anderson Cancer Center, Houston, TX.

出版信息

JCO Clin Cancer Inform. 2022 Mar;6(1):e2100193. doi: 10.1200/CCI.21.00193.

DOI:10.1200/CCI.21.00193
PMID:35404674
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9012601/
Abstract
摘要

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JAMA Oncol. 2021 Apr 1;7(4):603-608. doi: 10.1001/jamaoncol.2020.7310.
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Homologous recombination deficiency and host anti-tumor immunity in triple-negative breast cancer.三阴性乳腺癌中的同源重组缺陷和宿主抗肿瘤免疫。
Breast Cancer Res Treat. 2018 Aug;171(1):21-31. doi: 10.1007/s10549-018-4807-x. Epub 2018 May 7.
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Addition of the PARP inhibitor veliparib plus carboplatin or carboplatin alone to standard neoadjuvant chemotherapy in triple-negative breast cancer (BrighTNess): a randomised, phase 3 trial.在三阴性乳腺癌（BrighTNess）中，将 PARP 抑制剂 veliparib 联合卡铂或卡铂单药添加到标准新辅助化疗中：一项随机、3 期试验。
Lancet Oncol. 2018 Apr;19(4):497-509. doi: 10.1016/S1470-2045(18)30111-6. Epub 2018 Feb 28.
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Adaptive Randomization of Veliparib-Carboplatin Treatment in Breast Cancer.维利帕尼-卡铂治疗乳腺癌的适应性随机分组
N Engl J Med. 2016 Jul 7;375(1):23-34. doi: 10.1056/NEJMoa1513749.
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The Role of Proliferation in Determining Response to Neoadjuvant Chemotherapy in Breast Cancer: A Gene Expression-Based Meta-Analysis.增殖在确定乳腺癌新辅助化疗反应中的作用：基于基因表达的荟萃分析。
Clin Cancer Res. 2016 Dec 15;22(24):6039-6050. doi: 10.1158/1078-0432.CCR-16-0471. Epub 2016 Jun 21.
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Refinement of Triple-Negative Breast Cancer Molecular Subtypes: Implications for Neoadjuvant Chemotherapy Selection.三阴性乳腺癌分子亚型的细化：对新辅助化疗选择的影响
PLoS One. 2016 Jun 16;11(6):e0157368. doi: 10.1371/journal.pone.0157368. eCollection 2016.
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Data Sharing.数据共享。
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Tailoring adjuvant chemotherapy regimens for patients with triple negative breast cancer.为三阴性乳腺癌患者量身定制辅助化疗方案。
Breast. 2015 Nov;24 Suppl 2:S132-5. doi: 10.1016/j.breast.2015.07.032. Epub 2015 Aug 5.
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Phase II Study of Gemcitabine, Carboplatin, and Iniparib As Neoadjuvant Therapy for Triple-Negative and BRCA1/2 Mutation-Associated Breast Cancer With Assessment of a Tumor-Based Measure of Genomic Instability: PrECOG 0105.吉西他滨、卡铂和依尼帕利作为三阴性及BRCA1/2突变相关乳腺癌新辅助治疗的II期研究，并评估基于肿瘤的基因组不稳定性指标：PrECOG 0105。
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Clin Cancer Res. 2015 Apr 1;21(7):1688-98. doi: 10.1158/1078-0432.CCR-14-0432. Epub 2014 Sep 10.