Department of Ophthalmology & Vision Sciences, University of Toronto, Toronto, ON, Canada.
Department of Ophthalmology, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia.
Ocul Immunol Inflamm. 2023 May;31(4):826-829. doi: 10.1080/09273948.2022.2048028. Epub 2022 Apr 11.
To report a rare case of fungal keratitis and endophthalmitis due to .
Case report.
A 71-year-old immunocompetent male sustained a corneal laceration, traumatic cataract, and retinal detachment due to penetrating injury from a nail pulled from a wooden deck. The patient's postoperative course was complicated by infectious keratitis. Fungal cultures, DNA sequencing and analysis of the internal transcribed spacer sequence confirmed . Topical and oral voriconazole treatments were initiated; however, due to impending perforation, a therapeutic corneal transplant was required. One year later, the patient developed a new corneal infiltrate at the graft-host junction: Corneal scrapings were culture positive for . This was treated with topical and intrastromal voriconazole along with oral itraconazole 200 mg once daily for 8 months.
may cause recalcitrant keratitis and endophthalmitis, which required longstanding antifungal treatment.
报告一例由引起的真菌性角膜炎和眼内炎的罕见病例。
病例报告。
一名 71 岁免疫功能正常的男性因从木制甲板上拔出的钉子导致穿透性损伤而发生角膜裂伤、外伤性白内障和视网膜脱离。患者术后出现感染性角膜炎。真菌培养、DNA 测序和内部转录间隔区序列分析证实为。开始进行局部和口服伏立康唑治疗；然而，由于即将穿孔，需要进行治疗性角膜移植。一年后，患者在移植物与宿主交界处出现新的角膜浸润：角膜刮片培养出阳性。给予局部和基质内伏立康唑以及口服伊曲康唑 200mg，每日一次，共 8 个月进行治疗。
可能引起难治性角膜炎和眼内炎，需要长期抗真菌治疗。
