Yu Wenxin, Chen Yanyu, Cen Qingqing, Zhu Jiafang, Lin Xiaoxi
Departments of Laser and Aesthetic Medicine, and.
Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Dermatol Surg. 2022 May 1;48(5):534-538. doi: 10.1097/DSS.0000000000003410. Epub 2022 Apr 11.
Studies have demonstrated that glycerol can act as an optical clearing agent (OCA) to increase the light penetration through the skin and laser deposition to the target chromophore, thus potentially increasing the efficacy of laser treatment.
To evaluate whether a pulsed dye laser (PDL) in combination with an OCA can increase the efficacy in treating port-wine stains (PWSs).
Thirteen patients with untreated PWSs underwent 3 treatment sessions at 6-week intervals. Each PWS was divided into OCA + PDL sites (PDL treatment after topical use of 0.5 mL hydrous glycerol for 5 minutes), PDL sites, and untreated sites. The chromametric evaluation and visual evaluation (VAS) of the efficacy and the assessment of side effects were conducted 3 months after the final treatment.
Visual evaluation was 2.69 versus 2.07 (p = .025) and 3.38 versus 3.07 (p = .04) for OCA + PDL and PDL-only sites after the first and second sessions. After the third session, the chromameter and VAS indicated no significant difference between the 2 sites. Permanent side effects were not observed.
Greater efficacy was observed after the first 2 treatments on the OCA + PDL sites. Although after multiple sessions, the OCA + PDL treatment did not improve efficacy over just PDL alone.
研究表明，甘油可作为一种光学透明剂（OCA），增加光线透过皮肤的能力以及激光对目标发色团的沉积，从而有可能提高激光治疗的效果。
评估脉冲染料激光（PDL）联合OCA是否能提高治疗鲜红斑痣（PWS）的疗效。
13例未经治疗的PWS患者每隔6周接受3次治疗。每个PWS均分为OCA + PDL部位（局部使用0.5 mL含水甘油5分钟后进行PDL治疗）、PDL部位和未治疗部位。在最后一次治疗3个月后进行疗效的色度评估和视觉评估（VAS）以及副作用评估。
第一次和第二次治疗后，OCA + PDL部位与仅PDL部位的视觉评估分别为2.69对2.07（p = 0.025）和3.38对3.07（p = 0.04）。第三次治疗后，色度计和VAS显示这两个部位之间无显著差异。未观察到永久性副作用。
在前两次治疗中，OCA + PDL部位观察到了更高的疗效。尽管经过多次治疗后，OCA + PDL治疗并未比单纯PDL治疗提高疗效。
