Altermatt H J, Gebbers J O, Arnold W, Laissue J A
Laryngol Rhinol Otol (Stuttg). 1986 Oct;65(10):570-4.
Submucosal injections of teflon paste (suspension of teflon in glycerin) are used for therapy of ENT diseases. Little is known about the fate of the injected teflon particles. Is teflon phagocytosed and removed? Teflon paste was injected into the peritoneum of mice. After 48 days, we have found many teflon particles in peritoneal macrophages, in microphages and macrophages of regional lymph nodes and the spleen, and in Kupffer cells of the liver. We assume that phagocytosis and removal of the injected teflon particles occur in the patient, too. The particles are indigestible and, therefore, may block the phagocytic system. Phagocytes containing teflon induce local inflammation and fibrosis. Conclusive information about late effects is not available.
黏膜下注射聚四氟乙烯糊剂（聚四氟乙烯在甘油中的悬浮液）用于耳鼻喉疾病的治疗。关于注射的聚四氟乙烯颗粒的去向知之甚少。聚四氟乙烯会被吞噬并清除吗？将聚四氟乙烯糊剂注入小鼠腹膜。48天后，我们在腹膜巨噬细胞、局部淋巴结和脾脏的微巨噬细胞和巨噬细胞以及肝脏的库普弗细胞中发现了许多聚四氟乙烯颗粒。我们推测患者体内也会发生注射的聚四氟乙烯颗粒的吞噬和清除。这些颗粒无法消化，因此可能会阻塞吞噬系统。含有聚四氟乙烯的吞噬细胞会引发局部炎症和纤维化。关于后期影响的确凿信息尚无定论。
