Balmukhanov S B, Rismukhamedova R S, Abdrakhmanov Zh N, Musapirova N A, Aĭtkulova Z
Med Radiol (Mosk). 1986 Dec;31(12):16-9.
A clinical trial was performed in 339 patients with Stages IIB, IIIB cervical carcinoma to test the effect of radiotherapy in combination with metronidazole. When the overall material was evaluated, no significant difference in the local clearance rate of tumors in metronidazole-treated and untreated patients was revealed. However, when the case material was subdivided into a group of anemic patients (hemoglobin less than 120 g/l) and a group of patients with normal hemoglobin levels (hemoglobin greater than 120 g/l) the data indicated that metronidazole therapy improved significantly the results in the anemic patients. The results in the non-anemic patients were not influenced, to any significant extent, by the drug.
对339例IIB期、IIIB期宫颈癌患者进行了一项临床试验，以测试放疗联合甲硝唑的效果。对全部病例资料进行评估时，未发现甲硝唑治疗组和未治疗组患者肿瘤局部清除率有显著差异。然而，当将病例资料细分为贫血患者组（血红蛋白低于120g/l）和血红蛋白水平正常的患者组（血红蛋白高于120g/l）时，数据表明甲硝唑治疗显著改善了贫血患者的治疗效果。该药物对非贫血患者的治疗效果没有产生任何显著影响。
