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进化生物学如何解释为何只有人类女性和少数海洋哺乳动物雌性会经历更年期。

How evolutionary biology can explain why human and a few marine mammal females are the only ones that are menopausal.

作者信息

Dalton Dave

出版信息

J Theor Biol. 2022 Jun 21;543:111123. doi: 10.1016/j.jtbi.2022.111123. Epub 2022 Apr 8.

DOI:10.1016/j.jtbi.2022.111123
PMID:35405202
Abstract

Two fundamental questions related to menopause that have not been answered are: (1) why does menopause even occur? And, (2) of the more than six thousand known mammals extant today, why human and four whale females are the only ones that are menopausal? Answers to both of these basic questions are provided here on the basis of evolutionary biology. From observational data, it was found that there are three elemental criteria that all menopausal species must fulfill: first, it has to be long-lived (average female lifespan of the species has to be forty years or more); second, it must live in groups; and third, the average female-male lifespan differential has to be at least thirty percent or more. In addition, a corollary criterion for menopause was also established: for a species' females to be menopausal, the Encephalization Quotient (EQ) for the species has to be 2.5 or more. Though humans do not fulfill the third menopausal criterion currently, it has been shown that when the menopausal mechanism first became common in human ancestors, in all likelihood, that principle was conformed to. Of the multitude of mammals around, only a few species satisfy all three menopausal criteria, and hence are the only ones whose females undergo the menopausal process. Many hitherto unanswered questions with respect to menopause, such as, while long and short-finned pilot whales are close to each other both genetically and physiologically, why short-finned females are menopausal while long-finned females are not, why orca females are menopausal while elephant females are not, in spite of both being long-lived, etc., can be answered on the basis of those three criteria. Why there was no selection pressure for males to undergo advanced-age reproductive cessation in those few menopausal species and why the majority of divorces occur in mid-life (40-to-60s) are also explained from a menopausal perspective.

摘要

与更年期相关的两个尚未得到解答的基本问题是

(1)为什么会出现更年期?以及,(2)在当今现存的六千多种已知哺乳动物中,为什么只有人类女性和四种鲸类雌性会经历更年期?本文基于进化生物学对这两个基本问题给出了答案。从观测数据中发现,所有经历更年期的物种都必须满足三个基本标准:第一,必须长寿(该物种雌性的平均寿命必须达到40岁或以上);第二,必须群居;第三,雌性与雄性的平均寿命差异必须至少达到30%或更多。此外,还确立了一个关于更年期的推论标准:一个物种的雌性若要经历更年期,该物种的脑化指数(EQ)必须达到2.5或更高。虽然人类目前并不满足第三个更年期标准,但研究表明,当更年期机制在人类祖先中首次普遍出现时,很可能是符合这一原则的。在众多哺乳动物中,只有少数物种满足所有三个更年期标准,因此只有它们的雌性会经历更年期过程。许多关于更年期的此前未得到解答的问题,比如,尽管长鳍领航鲸和短鳍领航鲸在基因和生理上都很接近,但为什么短鳍雌性会经历更年期而长鳍雌性不会,为什么虎鲸雌性会经历更年期而大象雌性不会,尽管它们都长寿等等,都可以基于这三个标准得到解答。从更年期的角度还解释了为什么在那些少数经历更年期的物种中,雄性没有面临老年生殖停止的选择压力,以及为什么大多数离婚发生在中年(40到60岁)。

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