Division of Endocrinology and Diabetology, Department of Internal Medicine, Medical University of Graz, 8036 Graz, Austria.
Center on Aging and Mobility, University Hospital Zurich, City Hospital Waid&Triemli and University of Zurich, 8006 Zurich, Switzerland.
Nutrients. 2022 Mar 24;14(7):1360. doi: 10.3390/nu14071360.
Accumulating evidence suggests that potential cardiovascular benefits of vitamin D supplementation may be restricted to individuals with very low 25-hydroxyvitamin D (25(OH)D) concentrations; the effect of vitamin D on blood pressure (BP) remains unclear. We addressed this issue in a post hoc analysis of the double-blind, randomized, placebo-controlled Styrian Vitamin D Hypertension Trial (2011−2014) with 200 hypertensive patients with 25(OH)D levels <30 ng/mL. We evaluated whether 2800 IU of vitamin D3/day or placebo (1:1) for 8 weeks affects 24-hour systolic ambulatory BP in patients with 25(OH)D concentrations <20 ng/mL, <16 ng/mL, and <12 ng/mL and whether achieved 25(OH)D concentrations were associated with BP measures. Taking into account correction for multiple testing, p values < 0.0026 were considered significant. No significant treatment effects on 24-hour BP were observed when different baseline 25(OH)D thresholds were used (all p-values > 0.30). However, there was a marginally significant trend towards an inverse association between the achieved 25(OH)D level with 24-hour systolic BP (−0.196 per ng/mL 25(OH)D, 95% CI (−0.325 to −0.067); p = 0.003). In conclusion, we could not document the antihypertensive effects of vitamin D in vitamin D-deficient individuals, but the association between achieved 25(OH)D concentrations and BP warrants further investigations on cardiovascular benefits of vitamin D in severe vitamin D deficiency.
越来越多的证据表明，维生素 D 补充剂的潜在心血管益处可能仅限于 25-羟维生素 D（25(OH)D）浓度非常低的个体；维生素 D 对血压（BP）的影响仍不清楚。我们在一项双盲、随机、安慰剂对照的施蒂里亚维生素 D 高血压试验（2011-2014 年）的事后分析中解决了这个问题，该试验纳入了 200 名 25(OH)D 水平<30ng/mL 的高血压患者。我们评估了 2800IU 维生素 D3/天或安慰剂（1:1）治疗 8 周是否会影响 25(OH)D 浓度<20ng/mL、<16ng/mL 和<12ng/mL 的患者的 24 小时收缩压动态血压，以及达到的 25(OH)D 浓度是否与血压测量值相关。考虑到多次检验的校正，p 值<0.0026 被认为具有统计学意义。当使用不同的基线 25(OH)D 阈值时，未观察到治疗对 24 小时 BP 的显著影响（所有 p 值>0.30）。然而，达到的 25(OH)D 水平与 24 小时收缩压之间存在呈负相关的趋势（每 ng/mL 25(OH)D 降低 0.196，95%CI-0.325 至-0.067；p=0.003）。总之，我们不能证明维生素 D 在维生素 D 缺乏个体中的降压作用，但达到的 25(OH)D 浓度与 BP 之间的关联需要进一步研究严重维生素 D 缺乏症中维生素 D 的心血管益处。
