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心脏保护最佳补充剂的当前证据与未来展望:我们是否已迎来维生素的终章?

Current Evidence and Future Perspectives of the Best Supplements for Cardioprotection: Have We Reached the Final Chapter for Vitamins?

作者信息

Yasmin Farah, Ali Syed Hasan, Naeem Aisha, Savul Subhan, Afridi Muhammad Sohaib Iqbal, Kamran Neha, Fazal Fawwad, Khawer Shehryar, Savul Ilma Saleh, Najeeb Hala, Asim Hamdoon Suharwardy, Nausherwan Marium, Asghar Muhammad Sohaib

机构信息

Department of Internal Medicine, Dow Medical College, Dow University of Health Sciences, 74200 Karachi, Pakistan.

Department of Internal Medicine, Ziauddin University, 75000 Karachi, Pakistan.

出版信息

Rev Cardiovasc Med. 2022 Nov 9;23(11):381. doi: 10.31083/j.rcm2311381. eCollection 2022 Nov.

DOI:10.31083/j.rcm2311381
PMID:39076184
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11269067/
Abstract

Cardiovascular disease (CVD), a broad-spectrum term comprising coronary artery disease, stroke, hypertension, and heart failure, presents as one of the most significant strains on global healthcare systems. Coronary artery disease, caused by atherosclerosis, has various modifiable risk factors such as dietary changes and exercise. Since these risk factors are found to be linked to oxidative stress and inflammations, the dietary supplementation with vitamins' role in treating and preventing the diseases has been of much debate. With various vitamins having anti-inflammatory and antioxidative properties, studies have explored their correlation with cardiovascular health. Therefore, this narrative review explores and evaluates the benefits and risks of all vitamin supplementations in patients with CVD and provides future recommendations.

摘要

心血管疾病(CVD)是一个涵盖冠状动脉疾病、中风、高血压和心力衰竭的广义术语,是全球医疗系统面临的最重大压力之一。由动脉粥样硬化引起的冠状动脉疾病有多种可改变的风险因素,如饮食变化和运动。由于发现这些风险因素与氧化应激和炎症有关,维生素膳食补充剂在治疗和预防这些疾病中的作用一直备受争议。由于各种维生素具有抗炎和抗氧化特性,研究探讨了它们与心血管健康的相关性。因此,本叙述性综述探讨并评估了所有维生素补充剂对心血管疾病患者的益处和风险,并提供了未来建议。

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本文引用的文献

1
Effects of Vitamin D Supplementation on 24-Hour Blood Pressure in Patients with Low 25-Hydroxyvitamin D Levels: A Randomized Controlled Trial.补充维生素 D 对 25-羟维生素 D 水平较低患者 24 小时血压的影响:一项随机对照试验。
Nutrients. 2022 Mar 24;14(7):1360. doi: 10.3390/nu14071360.
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Vitamin B6 in Health and Disease.维生素 B6 在健康与疾病中的作用
Nutrients. 2021 Sep 17;13(9):3229. doi: 10.3390/nu13093229.
3
Efficacy and durability of multifactorial intervention on mortality and MACEs: a randomized clinical trial in type-2 diabetic kidney disease.
多因素干预对 2 型糖尿病肾病患者死亡率和主要不良心血管事件的疗效和持久性:一项随机临床试验。
Cardiovasc Diabetol. 2021 Jul 16;20(1):145. doi: 10.1186/s12933-021-01343-1.
4
The ViKTORIES trial: A randomized, double-blind, placebo-controlled trial of vitamin K supplementation to improve vascular health in kidney transplant recipients.ViKTORIES试验:一项关于补充维生素K以改善肾移植受者血管健康的随机、双盲、安慰剂对照试验。
Am J Transplant. 2021 Oct;21(10):3356-3368. doi: 10.1111/ajt.16566. Epub 2021 May 2.
5
β-blocker use and risk of all-cause mortality in patients with coronary heart disease: effect modification by serum vitamin A.β受体阻滞剂的使用与冠心病患者全因死亡率的关系:血清维生素 A 的作用修饰。
Eur J Prev Cardiol. 2022 Feb 3;28(17):1897-1902. doi: 10.1093/eurjpc/zwaa158.
6
The effects of magnesium and vitamin E co-supplementation on some cardiovascular risk factors: A meta-analysis.镁和维生素 E 联合补充对一些心血管危险因素的影响:一项荟萃分析。
Clin Nutr ESPEN. 2021 Feb;41:110-117. doi: 10.1016/j.clnesp.2020.10.021. Epub 2020 Nov 19.
7
Vitamin D and cardiovascular health.维生素 D 与心血管健康。
Clin Nutr. 2021 May;40(5):2946-2957. doi: 10.1016/j.clnu.2020.12.025. Epub 2020 Dec 29.
8
Effect of Vitamin D Supplementation, Omega-3 Fatty Acid Supplementation, or a Strength-Training Exercise Program on Clinical Outcomes in Older Adults: The DO-HEALTH Randomized Clinical Trial.维生素 D 补充、ω-3 脂肪酸补充或力量训练对老年人临床结局的影响:DO-HEALTH 随机临床试验。
JAMA. 2020 Nov 10;324(18):1855-1868. doi: 10.1001/jama.2020.16909.
9
The Association of Vitamin D and Vitamin K Status with Subclinical Measures of Cardiovascular Health and All-Cause Mortality in Older Adults: The Hoorn Study.维生素 D 和维生素 K 状态与老年人亚临床心血管健康和全因死亡率的关系:霍恩研究。
J Nutr. 2020 Dec 10;150(12):3171-3179. doi: 10.1093/jn/nxaa293.
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Vitamin D and Cardiovascular Disease, with Emphasis on Hypertension, Atherosclerosis, and Heart Failure.维生素 D 与心血管疾病,重点是高血压、动脉粥样硬化和心力衰竭。
Int J Mol Sci. 2020 Sep 4;21(18):6483. doi: 10.3390/ijms21186483.