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橄榄多酚颗粒复合物（主要为）的抗炎作用：体内和体外研究在炎症和 MIA 诱导的骨关节炎模型中的结果。

Anti-Inflammatory Effects Induced by a Polyphenolic Granular Complex from Olive (, Mainly ): Results from In Vivo and Ex Vivo Studies in a Model of Inflammation and MIA-Induced Osteoarthritis.

机构信息

Department of Pharmacy, "G. d'Annunzio" University, 66013 Chieti, Italy.

Department of Neuroscience, Psychology, Drug Research and Child Health-NEUROFARBA-Pharmacology and Toxicology Section, University of Florence, 50139 Florence, Italy.

出版信息

Nutrients. 2022 Apr 2;14(7):1487. doi: 10.3390/nu14071487.

DOI:10.3390/nu14071487
PMID:35406100
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9002755/
Abstract

MOMAST GR25 is a polyphenolic granular complex from olive pressing juice with high total content in polyphenols. In this work, we evaluated the possible anti-inflammatory effects of MOMAST GR25 in both acute and chronic inflammatory models. MOMAST GR25 decreased the levels of prostaglandin (PG) E and 8-iso-PGF in isolated rat colon, liver, and heart specimens stimulated with lipopolysaccharide (LPS). In vivo, compared to controls, rats treated with MOMAST GR25 (100 mg/kg to 1 g/kg) showed a significant reduction in both licking/biting time in the formalin test. In a rat model of osteoarthritis by monoiodoacetate (MIA) injection, MOMAST GR25 showed pain-relieving properties when acutely administered, reducing mechanical hyperalgesia and spontaneous pain. Moreover, a repeated daily treatment with MOMAST GR25 (300 mg/kg) fully counteracted osteoarticular pain without the development of tolerance to the antinociceptive effect. Taken together, our present findings showed that MOMAST GR25 could represent a potential strategy for the treatment of inflammation and pain.

摘要

MOMAST GR25 是一种来自橄榄压榨汁的多酚颗粒复合物，总多酚含量很高。在这项工作中，我们评估了 MOMAST GR25 在急性和慢性炎症模型中的可能抗炎作用。MOMAST GR25 降低了脂多糖（LPS）刺激的离体大鼠结肠、肝脏和心脏标本中前列腺素（PG）E 和 8-异-PGF 的水平。在体内，与对照组相比，用 MOMAST GR25（100mg/kg 至 1g/kg）治疗的大鼠在福尔马林试验中舔/咬时间明显减少。在单碘乙酸（MIA）注射诱导的大鼠骨关节炎模型中，MOMAST GR25 急性给药时具有缓解疼痛的作用，可减轻机械性痛觉过敏和自发性疼痛。此外，重复每日给予 MOMAST GR25（300mg/kg）可完全对抗骨关节炎疼痛，而不会对镇痛作用产生耐受性。综上所述，我们目前的研究结果表明，MOMAST GR25 可能是治疗炎症和疼痛的一种潜在策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27b/9002755/404697ec3ef9/nutrients-14-01487-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27b/9002755/962e22021c94/nutrients-14-01487-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27b/9002755/d7136fb60d03/nutrients-14-01487-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27b/9002755/01c93cd740f3/nutrients-14-01487-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27b/9002755/404697ec3ef9/nutrients-14-01487-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27b/9002755/962e22021c94/nutrients-14-01487-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27b/9002755/d7136fb60d03/nutrients-14-01487-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27b/9002755/01c93cd740f3/nutrients-14-01487-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a27b/9002755/404697ec3ef9/nutrients-14-01487-g004.jpg

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