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核医学方法在妇科恶性肿瘤诊断与治疗中的综述

A Review of Nuclear Medicine Approaches in the Diagnosis and the Treatment of Gynecological Malignancies.

作者信息

Vahidfar Nasim, Farzanefar Saeed, Ahmadzadehfar Hojjat, Molloy Eóin N, Eppard Elisabeth

机构信息

Department of Nuclear Medicine, Vali-Asr Hospital, Tehran University of Medical Sciences, Tehran 1419733133, Iran.

Department of Nuclear Medicine, Klinikum Westfalen, 44309 Dortmund, Germany.

出版信息

Cancers (Basel). 2022 Mar 31;14(7):1779. doi: 10.3390/cancers14071779.

DOI:10.3390/cancers14071779
PMID:35406552
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8997132/
Abstract

Nuclear medicine is defined as the diagnosis and the treatment of disease using radiolabeled compounds known as radiopharmaceuticals. Single-photon emission computed tomography/computed tomography (SPECT/CT) and positron emission tomography/computer tomography (PET/CT) based radiopharmaceuticals have proven reliable in diagnostic imaging in nuclear medicine and cancer treatment. One of the most critical cancers that also relies on an early diagnosis is gynecological cancer. Given that approximately 25% of all cancers in developing countries are a subset of gynecological cancer, investigating this cancer subtype is of significant clinical worth, particularly in light of its high rate of mortality. With accurate identification of high grade distant abdominal endometrial cancer as well as extra abdominal metastases, 18F-Fluorodeoxyglucose ([F]FDG) PET/CT imaging is considered a valuable step forward in the investigation of gynecological cancer. Considering these factors, [F]FDG PET/CT imaging can assist in making management of patient therapy more feasible. In this literature review, we will provide a short overview of the role of nuclear medicine in the diagnosis of obstetric and gynecological cancers.

摘要

核医学被定义为使用称为放射性药物的放射性标记化合物来诊断和治疗疾病。基于单光子发射计算机断层扫描/计算机断层扫描（SPECT/CT）和正电子发射断层扫描/计算机断层扫描（PET/CT）的放射性药物已被证明在核医学诊断成像和癌症治疗中是可靠的。妇科癌症是最关键的癌症之一，也依赖于早期诊断。鉴于发展中国家所有癌症中约25%是妇科癌症的一个子集，研究这种癌症亚型具有重要的临床价值，特别是考虑到其高死亡率。凭借对高级别远处腹部子宫内膜癌以及腹部外转移的准确识别，18F-氟脱氧葡萄糖（[F]FDG）PET/CT成像被认为是妇科癌症研究中的一个有价值的进展。考虑到这些因素，[F]FDG PET/CT成像有助于使患者治疗管理更加可行。在这篇文献综述中，我们将简要概述核医学在妇产科癌症诊断中的作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1a0/8997132/00b352ba4dd9/cancers-14-01779-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1a0/8997132/fcd48769495b/cancers-14-01779-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1a0/8997132/0f01e148a217/cancers-14-01779-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1a0/8997132/b80a60c07ea2/cancers-14-01779-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1a0/8997132/a689308f306d/cancers-14-01779-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1a0/8997132/00b352ba4dd9/cancers-14-01779-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1a0/8997132/fcd48769495b/cancers-14-01779-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1a0/8997132/0f01e148a217/cancers-14-01779-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1a0/8997132/b80a60c07ea2/cancers-14-01779-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1a0/8997132/a689308f306d/cancers-14-01779-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1a0/8997132/00b352ba4dd9/cancers-14-01779-g005.jpg

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