Park M H, D'Agati V, Appel G B, Pirani C L
Nephron. 1986;44(4):309-19. doi: 10.1159/000184012.
The interrelationships between tubulointerstitial immune deposits (TID), interstitial inflammation, glomerular changes, renal function, and prognosis were assessed in the renal biopsies from 93 patients with lupus nephritis. The prevalence of TID was 33% by immunofluorescence and 23% by electron microscopy. Although predominantly detected along and within tubular basement membranes, extraglomerular immune deposits were also present in the wall of renal interstitial capillaries and small arteries as well as in Bowman's capsule. The prevalence of TID correlated with the activity of glomerular lesions and, to a lesser extent, with the severity of proliferative lupus nephritis (WHO classes II-IV). TID were much less common in the membranous form (WHO class V). The severity of interstitial inflammation correlated with the degree of renal insufficiency and was an accurate prognostic indicator of progressive deterioration of renal function. However, there was no correlation between prevalence of TID and prevalence and severity of interstitial inflammation, suggesting that the latter is not necessarily secondary to the presence of immune complexes and that other pathogenetic mechanisms may be involved.
对93例狼疮性肾炎患者的肾活检组织进行评估，以研究肾小管间质免疫沉积物（TID）、间质炎症、肾小球改变、肾功能及预后之间的相互关系。免疫荧光法检测TID的患病率为33%，电子显微镜法为23%。虽然主要在肾小管基底膜及其内发现，但肾小球外免疫沉积物也存在于肾间质毛细血管和小动脉壁以及鲍曼囊中。TID的患病率与肾小球病变的活动度相关，在较小程度上与增殖性狼疮性肾炎（WHO分级II-IV级）的严重程度相关。TID在膜性型（WHO分级V级）中少见得多。间质炎症的严重程度与肾功能不全的程度相关，是肾功能进行性恶化的准确预后指标。然而，TID的患病率与间质炎症的患病率及严重程度之间无相关性，提示后者不一定继发于免疫复合物的存在，可能涉及其他发病机制。
