Xanthopoulos Andrew, Giamouzis Grigorios, Dimos Apostolos, Skoularigki Evangelia, Starling Randall C, Skoularigis John, Triposkiadis Filippos
Department of Cardiology, University Hospital of Larissa, 41110 Larissa, Greece.
Kaufman Center for Heart Failure and Recovery, Heart, Vascular, and Thoracic Institute, Cleveland Clinic, Cleveland, OH 44195, USA.
J Clin Med. 2022 Mar 31;11(7):1951. doi: 10.3390/jcm11071951.
Red blood cell distribution width (RDW), an integral parameter of the complete blood count (CBC), has been traditionally used for the classification of several types of anemia. However, over the last decade RDW has been associated with outcome in patients with several cardiovascular diseases including heart failure. The role of RDW in acute, chronic and advanced heart failure is the focus of the present work. Several pathophysiological mechanisms of RDW's increase in heart failure have been proposed (i.e., inflammation, oxidative stress, adrenergic stimulation, undernutrition, ineffective erythropoiesis, reduced iron mobilization, etc.); however, the exact mechanism remains unknown. Although high RDW values at admission and discharge have been associated with adverse prognosis in hospitalized heart failure patients, the prognostic role of in-hospital RDW changes (ΔRDW) remains debatable. RDW has been incorporated in recent heart failure prognostic models. Utilizing RDW as a treatment target in heart failure may be a promising area of research.
红细胞分布宽度（RDW）是全血细胞计数（CBC）的一个重要参数，传统上一直用于几种贫血类型的分类。然而，在过去十年中，RDW已与包括心力衰竭在内的几种心血管疾病患者的预后相关联。RDW在急性、慢性和晚期心力衰竭中的作用是本研究的重点。已经提出了心力衰竭中RDW升高的几种病理生理机制（即炎症、氧化应激、肾上腺素能刺激、营养不良、无效红细胞生成、铁动员减少等）；然而，确切机制仍不清楚。尽管入院和出院时的高RDW值与住院心力衰竭患者的不良预后相关，但住院期间RDW变化（ΔRDW）的预后作用仍存在争议。RDW已被纳入最近的心力衰竭预后模型。将RDW用作心力衰竭的治疗靶点可能是一个有前景的研究领域。
