微波辅助合成、生物活性评价、分子对接及一些新型吡咯并[2,3-b]吡咯衍生物的 ADMET 研究。

Microwave-Assisted Synthesis, Biological Activity Evaluation, Molecular Docking, and ADMET Studies of Some Novel Pyrrolo [2,3-] Pyrrole Derivatives.

机构信息

Chemistry Department, Faculty of Science, Sohag University, Sohag 82524, Egypt.

Department of Pharmaceutical Chemistry, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.

出版信息

Molecules. 2022 Mar 23;27(7):2061. doi: 10.3390/molecules27072061.

Novel pyrrolo [2,3-] pyrrole derivatives were synthesized and their hypolipidemic activity was assessed in hyperlipidemic rats. The chemical structures of the new derivatives were confirmed through spectral analysis. Compounds and were revealed to be the most effective hypolipidemic agents, with considerable hypocholesterolemic and hypotriglyceridemic effects. They appear to be promising candidates for creating new powerful derivatives with anti-atherosclerotic and hypolipidemic properties. As for antimicrobial activity, some of the tested compounds showed moderate activity against : compound revealed an MIC value of 50 μg/mL, compared to 25 μg/mL for ciprofloxacin. Compound showed good antimicrobial activity against Staphylococcus aureus, comparable to ciprofloxacin, and roughly half the activity of ampicillin, according to MIC values. Compound has an MIC approximately 25% of that of clotrimazole against Candida albicans. Compound also showed the highest antioxidant activity with 59% inhibition of radical scavenging activity. Additionally, the cytotoxic activity of these new derivatives - was investigated and most of them showed good anticancer activity against the three tested cell lines.

新型吡咯并[2,3-]吡咯衍生物被合成，并在高血脂大鼠中评估其降血脂活性。新衍生物的化学结构通过光谱分析得到确认。化合物和被发现是最有效的降脂剂，具有显著的降胆固醇和降甘油三酯作用。它们似乎是具有抗动脉粥样硬化和降血脂特性的新型强效衍生物的有前途的候选物。至于抗菌活性，一些测试的化合物对表现出中等活性：化合物显示出 MIC 值为 50 μg/mL，而环丙沙星为 25 μg/mL。化合物对金黄色葡萄球菌表现出良好的抗菌活性，与环丙沙星相当，根据 MIC 值，约为氨苄西林的一半。化合物对白色念珠菌的 MIC 值约为克霉唑的 25%。化合物对自由基清除活性的抑制率也达到了 59%，具有最高的抗氧化活性。此外，还研究了这些新衍生物的细胞毒性作用-，它们中的大多数对三种测试的细胞系均显示出良好的抗癌活性。