大环含氮杂环的合成、配位及生物性能研究进展

Laboratory of Applied Chemistry and Environment-ECOMP, Faculty of Sciences, Mohammed First University, Bd Mohamed VI, Oujda 60000, Morocco.

Department of Pathology, College of Korean Medicine, Kyung Hee University, Seoul 02447, Korea.

Molecules. 2022 Mar 25;27(7):2123. doi: 10.3390/molecules27072123.

Macrocyclic chemistry has been extensively developed over the past several decades. In fact, the architecture of new macrocyclic models has undergone exponential growth to offer molecules with specific properties. In this context, an attempt is made in this study to provide an overview of some synthetic methods allowing the elaboration of N-heterocycles containing macrocycles (imidazole, triazole, tetrazole, and pyrazole), as well as their applications in the complexation of metal cations or as pharmacological agents.

大环化学在过去几十年中得到了广泛的发展。事实上，新型大环模型的结构呈指数级增长，为具有特定性质的分子提供了可能。在这种情况下，本研究试图概述一些允许合成含大环（咪唑、三唑、四唑和吡唑）的杂环的方法，以及它们在金属阳离子络合或作为药理学试剂方面的应用。