School of Chemical and Environmental Engineering, Anhui Polytechnic University, Wuhu 241000, China.
School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, China.
Molecules. 2022 Apr 4;27(7):2329. doi: 10.3390/molecules27072329.
Near-infrared dyes were developed to be contrast agents due to their ability to improve the productivity of photoacoustic (PA) imaging and photothermal therapy (PTT) treatments. During the article, we described in detail the PA and PT effects of a category of organic molecules. F-TCNQ could potentially cause a red-shift in the peak PA intensity. The results show that the PTT intensity of the near-infrared dyes with phenyl groups were higher than near-infrared dyes with thiophene groups. We also investigated the photodynamic treatment effect of C1b to demonstrate that these dyes are highly desirable in biochemistry. The high photoacoustic intensity of the organic molecules and the good yield of reactive oxygen species could indicate that these dyes have good potential for a wide range of imaging applications. Finally, we embedded the dye (C1b) in a liposomal hydrophobic phospholipid bilayer (C1b⊂L) to facilitate the application of hydrophobic dyes in biomedical applications, which can be absorbed by cells with good compatible and high stability for the imaging of cellular PA.
近红外染料因其能够提高光声（PA）成像和光热治疗（PTT）治疗的效率而被开发为对比剂。在本文中，我们详细描述了一类有机分子的 PA 和 PT 效应。F-TCNQ 可能导致 PA 强度峰值的红移。结果表明，具有苯基的近红外染料的 PTT 强度高于具有噻吩基团的近红外染料。我们还研究了 C1b 的光动力治疗效果，以证明这些染料在生物化学中具有很高的应用价值。有机分子的高光声强度和活性氧的高产量表明，这些染料具有广泛的成像应用的良好潜力。最后，我们将染料（C1b）嵌入脂质体疏水性磷脂双层（C1b⊂L）中，以促进疏水性染料在生物医学应用中的应用，这些染料可以被细胞吸收，具有良好的相容性和稳定性，可用于细胞的 PA 成像。
