动脉粥样硬化：从分子生物学到治疗视角。
Atherosclerosis: From Molecular Biology to Therapeutic Perspective.
机构信息
Centre for Microscopy and Microanalysis (CM2), Department of Biology, Ecology and Earth Sciences, University of Calabria, Arcavacata di Rende, 87036 Cosenza, Italy.
出版信息
Int J Mol Sci. 2022 Mar 22;23(7):3444. doi: 10.3390/ijms23073444.
Abstract
Atherosclerosis is a chronic and progressive inflammatory disease of the arteries initiated by the functional and structural alteration of the endothelial layer responsible for promoting the subendothelial retention of modified low-density lipoproteins (LDL), which in turn generate an active proinflammatory state in which environmental factors, such as oxidizing agents, growth factors, cytokines, monocyte-macrophages and smooth muscle cells (SMCs), work in cooperation to promote the formation of plaque [...].
摘要
动脉粥样硬化是一种由负责促进修饰的低密度脂蛋白（LDL）在血管内皮细胞下蓄积的内皮功能和结构改变引起的慢性进行性炎症性疾病，这反过来又会产生一个主动的促炎状态，其中环境因素，如氧化剂、生长因子、细胞因子、单核细胞-巨噬细胞和平滑肌细胞（SMCs），协同作用促进斑块的形成[... ]。
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