Dal Cortivo Giuditta, Dell'Orco Daniele
Department of Neurosciences, Biomedicine and Movement Sciences, Section of Biological Chemistry, University of Verona, 37134 Verona, Italy.
Int J Mol Sci. 2022 Mar 24;23(7):3552. doi: 10.3390/ijms23073552.
Calcium- and integrin-binding protein 2 (CIB2) is a small EF-hand protein capable of binding Mg and Ca ions. While its biological function remains largely unclear, an increasing number of studies have shown that CIB2 is an essential component of the mechano-transduction machinery that operates in cochlear hair cells. Mutations in the gene encoding CIB2 have been associated with non-syndromic deafness. In addition to playing an important role in the physiology of hearing, CIB2 has been implicated in a multitude of very different processes, ranging from integrin signaling in platelets and skeletal muscle to autophagy, suggesting extensive functional plasticity. In this review, we summarize the current understanding of biochemical and biophysical properties of CIB2 and the biological roles that have been proposed for the protein in a variety of processes. We also highlight the many molecular aspects that remain unclarified and deserve further investigation.
钙整合素结合蛋白2（CIB2）是一种能够结合镁离子和钙离子的小型EF手型蛋白。尽管其生物学功能在很大程度上仍不清楚，但越来越多的研究表明，CIB2是在耳蜗毛细胞中起作用的机械转导机制的重要组成部分。编码CIB2的基因突变与非综合征性耳聋有关。除了在听力生理中发挥重要作用外，CIB2还涉及许多非常不同的过程，从血小板和骨骼肌中的整合素信号传导到自噬，这表明它具有广泛的功能可塑性。在这篇综述中，我们总结了目前对CIB2生化和生物物理特性的理解，以及该蛋白在各种过程中所发挥的生物学作用。我们还强调了许多尚未阐明且值得进一步研究的分子方面。
