Department of Environment and Health, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan 250012, China.
Key Laboratory of High Efficiency and Clean Mechanical Manufacture, Ministry of Education, School of Mechanical Engineering, Shandong University, Jinan 250061, China.
Int J Environ Res Public Health. 2022 Mar 31;19(7):4167. doi: 10.3390/ijerph19074167.
Chlortetracycline (CTC), which has been frequently detected in surface water, is generated primarily by the discharge of high-concentration CTC wastewater from pharmaceutical and livestock plants. The development of effective CTC degradation technology is critical. In this study, the extent of CTC degradation at 80 mg/L was investigated by combining hydrodynamic cavitation (HC) and hydrogen peroxide (HO). The results indicate degradation ratios of 88.7% and 93.8% at 5 and 30 min, respectively. Furthermore, the possible mechanisms of CTC degradation were determined via HPLC-MS. The CTC degradation pathways include ring openings, C-N bond cleavage, demethylation, dehydroxylation, and desaturation in the sole system of HC, and a series of additional reactions, such as glycine conjugation and the cleavage of C-C double bonds, occurs in the binary system of HC + HO. Nevertheless, the treated water poses ecological risks and cannot be directly discharged into the environment. Therefore, HC + HO treatment may be a rapid and effective primary method for the degradation of high-concentration CTC in pharmaceutical factories.
金霉素（CTC）在地表水中频繁检出，主要来源于制药厂和养殖场高浓度 CTC 废水的排放。开发有效的 CTC 降解技术至关重要。本研究将水力空化（HC）和过氧化氢（HO）相结合，考察了 80mg/L CTC 的降解程度。结果表明，分别在 5min 和 30min 时的降解率为 88.7%和 93.8%。此外，通过高效液相色谱-质谱联用仪（HPLC-MS）确定了 CTC 降解的可能机制。在 HC 单一体系中，CTC 的降解途径包括开环、C-N 键断裂、去甲基化、去羟化和去饱和，而在 HC+HO 二元体系中还发生了一系列其他反应，如甘氨酸结合和 C-C 双键的断裂。然而，处理后的水具有生态风险，不能直接排放到环境中。因此，HC+HO 处理可能是制药厂中高浓度 CTC 降解的一种快速有效的初步方法。
