Nguyen Thanh Xuan, Nguyen Van Tri, Nguyen-Phan Hong Ngoc, Hoang Bui Bao
Department of Abdominal Emergency and Pediatric Surgery, Hue Central Hospital, Hue City, 530000, Vietnam.
Department of Anesthesiology, Hue International Medical Center, Hue Central Hospital, Hue City, 530000, Vietnam.
Integr Blood Press Control. 2022 Apr 7;15:43-51. doi: 10.2147/IBPC.S360584. eCollection 2022.
This study aims to determine the serum levels of NT-proBNP in women with preeclampsia with and without severe signs and to evaluate the cardiovascular risks in these two groups of participants.
A descriptive cross-sectional study was conducted on 52 women with preeclampsia in the Department of Gynecology and Obstetrics - Hue Central Hospital, from August 2019 to September 2020.
In preeclampsia women, the rate of hypertension in stage 3, stage 2, and stage 1 were 46.1%, 32.7%, and 21.2%, respectively. The average Sokolow-Lyon index in the preeclampsia group with and without severe signs was 22.25 ± 7.38mm, 20.16 ± 5.54mm, respectively. The average left ventricular mass index in the group of preeclampsia patients without and with severe signs was 92.27 ± 14.56g/m and 120.68 ± 16.47g/m, respectively. The average ejection fraction in the group of preeclampsia patients without severe signs and with severe signs was 65.11 ± 3.45%, 56.21 ± 7.12%, correspondingly. In contrast, the difference between the two groups was statistically significant with p < 0.05. The plasma NT-proBNP level in the preeclampsia group without severe signs was 349.12 ± 93.51pg/mL, whereas the concentration in the preeclampsia group with severe signs was 725.32 ± 290.46pg/mL (p < 0.05).
The NT-proBNP level was statistically significantly increased in the patients with preeclampsia. Analyzing and comparing the figures and changes found in two groups of PE patients, with and without severe signs, we suggest that women diagnosed with PE with severe signs have a higher risk of developing cardiovascular problems forthwith and henceforth.
本研究旨在测定有严重体征和无严重体征的子痫前期女性的血清NT-proBNP水平，并评估这两组参与者的心血管风险。
2019年8月至2020年9月，在顺化中心医院妇产科对52例子痫前期女性进行了描述性横断面研究。
子痫前期女性中，3期、2期和1期高血压的发生率分别为46.1%、32.7%和21.2%。有严重体征和无严重体征的子痫前期组的平均索科洛夫-里昂指数分别为22.25±7.38mm、20.16±5.54mm。无严重体征和有严重体征的子痫前期患者组的平均左心室质量指数分别为92.27±14.56g/m和120.68±16.47g/m。无严重体征和有严重体征的子痫前期患者组的平均射血分数分别为65.11±3.45%、56.21±7.12%，相应地。相比之下，两组之间的差异具有统计学意义，p<0.05。无严重体征的子痫前期组血浆NT-proBNP水平为349.12±93.51pg/mL，而有严重体征的子痫前期组浓度为725.32±290.46pg/mL（p<0.05）。
子痫前期患者的NT-proBNP水平在统计学上显著升高。通过分析和比较有严重体征和无严重体征的两组子痫前期患者的数据及变化，我们认为被诊断为有严重体征的子痫前期女性即刻及今后发生心血管问题的风险更高。
