Liu Caiyun, Li Xinjian
CAS Key Laboratory of Infection and Immunity, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China.
College of Life Sciences, University of Chinese Academy of Sciences, Beijing, China.
Mol Cell Oncol. 2021 Dec 8;8(6):2009423. doi: 10.1080/23723556.2021.2009423. eCollection 2021.
How cancer cells absorb enough glucose to support their rapid growth is poorly understood. We have recently demonstrated that palmitoyl transferase DHHC9 palmitoylates glucose transporter GLUT1 at Cys207 to maintain GLUT1 plasma membrane localization. DHHC9-mediated GLUT1 palmitoylation supports glycolysis, proliferation, colony formation, and tumorigenicity of glioblastoma cells.
癌细胞如何摄取足够的葡萄糖以支持其快速生长，目前还知之甚少。我们最近证明，棕榈酰转移酶DHHC9在半胱氨酸207位点使葡萄糖转运蛋白GLUT1发生棕榈酰化，以维持GLUT1在质膜上的定位。DHHC9介导的GLUT1棕榈酰化支持胶质母细胞瘤细胞的糖酵解、增殖、集落形成和致瘤性。
