Department of Ophthalmology, Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Kongjiang Road, No. 1665, Shanghai, 200092, China.
Int Ophthalmol. 2022 Sep;42(9):2871-2879. doi: 10.1007/s10792-022-02277-7. Epub 2022 Apr 13.
To investigate the clinical features and surgical outcomes in infants with glaucoma secondary to a special anterior-anterior type of persistent fetal vasculature (AAPFV).
This study retrospectively reviewed the medical records of infants who underwent of the synechialysis, pupilloplasty, with or without lensectomy and limbal vitrectomy due to AAPFV and with at least 6 months of postoperative follow-up.
Eleven patients were included. The median age at surgery was 4.0 months (interquartile range: 7 months). The mean follow-up was 21.0 ± 11.3 months. All patients achieved a normal anterior chamber, improved pupillary configuration, and normal intraocular pressure (IOP), except one that developed phthisis bulbi at the last visit. A total of 81.8% (9/11) eyes exhibited improved corneal transparency. Histopathologic findings of four pupillary membranous specimens under light microscopy showed similar components compared with PFV. Two eyes developed postoperative complications, including retinal detachment and hyphema, requiring additional surgeries. Postoperative visual acuity changed from no light perception to light perception in 6/9 patients.
AAPFV is a special type of PFV with a potential for secondary glaucoma. Surgery treatment may offer better vision with improved cosmetic outcomes and a better controlled IOP.
The study was approved by the local institutional review board (IRB) (Approval No. XHEC-D-2021-043, Ethical Committee of Xin Hua Hospital Affiliated to Shanghai Jiao Tong University, Shanghai, China).
研究一种特殊的永存原始前体血管性（PFV）前房-前房型继发青光眼的临床特征和手术效果。
本研究回顾性分析了 11 例因 AAPFV 行房角切开术、瞳孔成形术，联合或不联合晶状体切除术和角巩膜缘玻璃体切除术，并至少有 6 个月术后随访的婴儿的病历。
纳入 11 例患者。手术时的中位年龄为 4.0 个月（四分位距：7 个月）。平均随访时间为 21.0±11.3 个月。除最后一次就诊时有 1 例发生眼球萎缩外，所有患者均在前房正常、瞳孔形态改善和眼压（IOP）正常。共有 81.8%（9/11）的眼改善了角膜透明度。4 例瞳孔膜组织的组织病理学检查结果在光镜下显示与 PFV 相似的成分。2 只眼术后发生视网膜脱离和前房积血等并发症，需要进一步手术。术后视力从无光感提高到光感的有 6/9 例。
AAPFV 是一种特殊类型的 PFV，可能继发青光眼。手术治疗可能提供更好的视力、改善美容效果和更好地控制 IOP。
该研究得到了当地机构审查委员会（IRB）的批准（批准号：XHEC-D-2021-043，上海交通大学附属新华医院伦理委员会，中国上海）。
