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癫痫大鼠点燃模型中海马γ-氨基丁酸（GABA）免疫反应性细胞数量减少。

Decrease in number of hippocampal gamma-aminobutyric acid (GABA) immunoreactive cells in the rat kindling model of epilepsy.

作者信息

Kamphuis W, Wadman W J, Buijs R M, Lopes da Silva F H

出版信息

Exp Brain Res. 1986;64(3):491-5. doi: 10.1007/BF00340486.

DOI:10.1007/BF00340486
PMID:3542543
Abstract

Daily repeated tetanic electrical stimulation (kindling) of hippocampus or other brain structures leads to progressive increase in epileptiform activity. Since kindling may involve changes in the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), the distribution of this amino acid was studied. A significant decrease in number of GABA immunoreactive positive cell bodies in stimulated CA1 region of the rat hippocampus compared to the contralateral side was found.

摘要

对海马体或其他脑结构进行每日重复的强直电刺激（点燃）会导致癫痫样活动逐渐增加。由于点燃可能涉及抑制性神经递质γ-氨基丁酸（GABA）的变化，因此对这种氨基酸的分布进行了研究。结果发现，与对侧相比，大鼠海马体受刺激的CA1区域中GABA免疫反应阳性细胞体的数量显著减少。

相似文献

1
Decrease in number of hippocampal gamma-aminobutyric acid (GABA) immunoreactive cells in the rat kindling model of epilepsy.癫痫大鼠点燃模型中海马γ-氨基丁酸（GABA）免疫反应性细胞数量减少。
Exp Brain Res. 1986;64(3):491-5. doi: 10.1007/BF00340486.
2
The development of changes in hippocampal GABA immunoreactivity in the rat kindling model of epilepsy: a light microscopic study with GABA antibodies.癫痫大鼠点燃模型中海马γ-氨基丁酸免疫反应性变化的发展：用γ-氨基丁酸抗体进行的光镜研究
Neuroscience. 1987 Nov;23(2):433-46. doi: 10.1016/0306-4522(87)90067-4.
3
Decrease in GABA immunoreactivity and alteration of GABA metabolism after kindling in the rat hippocampus.大鼠海马点燃后GABA免疫反应性降低及GABA代谢改变。
Exp Brain Res. 1989;74(2):375-86. doi: 10.1007/BF00248871.
4
Kindling induced changes in parvalbumin immunoreactivity in rat hippocampus and its relation to long-term decrease in GABA-immunoreactivity.
Brain Res. 1989 Feb 6;479(1):23-34. doi: 10.1016/0006-8993(89)91331-0.
5
Kindling increases the K(+)-evoked Ca2(+)-dependent release of endogenous GABA in area CA1 of rat hippocampus.点燃效应增加了大鼠海马体CA1区钾离子诱发的内源性γ-氨基丁酸（GABA）的钙离子依赖性释放。
Brain Res. 1990 Mar 12;511(1):63-70. doi: 10.1016/0006-8993(90)90225-z.
6
Development of changes in endogenous GABA release during kindling epileptogenesis in rat hippocampus.大鼠海马点燃癫痫发生过程中内源性γ-氨基丁酸释放变化的发展
Brain Res. 1991 Apr 5;545(1-2):33-40. doi: 10.1016/0006-8993(91)91266-4.
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Electrically evoked GABA release in rat hippocampus CA1 region and its changes during kindling epileptogenesis.大鼠海马CA1区电诱发γ-氨基丁酸释放及其在点燃癫痫发生过程中的变化。
Brain Res. 2007 Mar 2;1135(1):69-76. doi: 10.1016/j.brainres.2006.12.004. Epub 2007 Jan 2.
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Amygdala-kindling induces a lasting reduction of GABA-immunoreactive neurons in a discrete area of the ipsilateral piriform cortex.杏仁核点燃诱导同侧梨状皮质离散区域中γ-氨基丁酸免疫反应性神经元的持续减少。
Synapse. 1998 Aug;29(4):299-309. doi: 10.1002/(SICI)1098-2396(199808)29:4<299::AID-SYN2>3.0.CO;2-0.
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Changes in extracellular levels of amygdala amino acids in genetically fast and slow kindling rat strains.基因快速和慢速点燃大鼠品系杏仁核氨基酸细胞外水平的变化。
Brain Res. 2002 Aug 9;946(1):31-42. doi: 10.1016/s0006-8993(02)02821-4.
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A long-lasting decrease in the inhibitory effect of GABA on glutamate responses of hippocampal pyramidal neurons induced by kindling epileptogenesis.点燃癫痫发生诱导的海马锥体神经元γ-氨基丁酸（GABA）对谷氨酸反应抑制作用的长期降低。
Neuroscience. 1991;41(2-3):425-31. doi: 10.1016/0306-4522(91)90338-o.

引用本文的文献

1
Effects of Low Frequency Stimulation on Spontaneous Inhibitory and Excitatory Post-Synaptic Currents in Hippocampal CA1 Pyramidal Cells of Kindled Rats.低频刺激对点燃大鼠海马CA1锥体细胞自发性抑制性和兴奋性突触后电流的影响
Cell J. 2017 Winter;18(4):547-555. doi: 10.22074/cellj.2016.4721. Epub 2016 Sep 26.
2
Morphological and functional consequences of chronic epilepsy in rat hippocampal slice cultures.大鼠海马切片培养物中慢性癫痫的形态学和功能后果。
Pflugers Arch. 1993 Jan;422(4):418-23. doi: 10.1007/BF00374304.
3
Reversible loss of dendritic spines and altered excitability after chronic epilepsy in hippocampal slice cultures.

本文引用的文献

1
Pharmacological investigation of gamma aminobutyric acid (GABA) and the development of amygdala-kindled seizures in the rat.γ-氨基丁酸（GABA）的药理学研究及大鼠杏仁核点燃性癫痫的发展
Exp Neurol. 1981 Dec;74(3):829-36. doi: 10.1016/0014-4886(81)90255-7.
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Cerebral free amino acids in the amygdaloid kindling model of epilepsy.
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Pharmacological investigation of gamma-aminobutyric acid (GABA) and fully-developed generalized seizures in the amygdala-kindled rat.γ-氨基丁酸（GABA）与杏仁核点燃大鼠完全性全身性癫痫发作的药理学研究。
海马切片培养物中慢性癫痫发作后树突棘的可逆性丧失及兴奋性改变
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Inhibitory processes in development of seizure activity in hippocampal slices.海马切片癫痫活动发展中的抑制过程。
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Calcium and epileptogenesis.钙与癫痫发生。
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Decrease in GABA immunoreactivity and alteration of GABA metabolism after kindling in the rat hippocampus.大鼠海马点燃后GABA免疫反应性降低及GABA代谢改变。
Exp Brain Res. 1989;74(2):375-86. doi: 10.1007/BF00248871.
7
Changes in GABA-immunoreactive cell density during motor focal epilepsy induced by cobalt in the rat.大鼠钴诱导的局灶性运动性癫痫发作期间GABA免疫反应性细胞密度的变化。
Exp Brain Res. 1989;76(2):369-85. doi: 10.1007/BF00247895.
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GABA neurons in seizure disorders: a review of immunocytochemical studies.癫痫疾病中的γ-氨基丁酸能神经元：免疫细胞化学研究综述
Neurochem Res. 1991 Mar;16(3):295-308. doi: 10.1007/BF00966093.
9
Alterations of GABA metabolism and seizure susceptibility in the substantia nigra of the kindled rat acclimating to changes in osmotic state.点燃大鼠适应渗透状态变化时黑质中γ-氨基丁酸代谢及癫痫易感性的改变。
Neurochem Res. 1991 Mar;16(3):269-78. doi: 10.1007/BF00966090.
Neuropharmacology. 1982 Feb;21(2):127-31. doi: 10.1016/0028-3908(82)90151-4.
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Antibodies against gamma-aminobutyric acid: specificity studies and immunocytochemical results.抗γ-氨基丁酸抗体：特异性研究及免疫细胞化学结果
Proc Natl Acad Sci U S A. 1984 Jun;81(12):3888-92. doi: 10.1073/pnas.81.12.3888.
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Evidence implicating substantia nigra in regulation of kindled seizure threshold.有证据表明黑质参与点燃癫痫阈值的调节。
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The effects of kindling on GABA-mediated inhibition in the dentate gyrus of the rat. I. Paired-pulse depression.点燃对大鼠齿状回中γ-氨基丁酸介导的抑制作用的影响。I. 双脉冲抑制
Brain Res. 1983 Oct 24;277(1):79-90. doi: 10.1016/0006-8993(83)90909-5.
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Two types of interictal transients of reversed polarity in rat hippocampus during kindling.点燃过程中大鼠海马区两种发作间期极性反转的瞬态变化
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The kindling model of epilepsy: a review.癫痫的点燃模型：综述
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A permanent change in brain function resulting from daily electrical stimulation.每日电刺激导致的大脑功能永久性改变。
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Modification of seizure activity by electrical stimulation. II. Motor seizure.电刺激对癫痫发作活动的影响。II. 运动性癫痫
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