Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, California, USA.
Memory and Aging Center, University of California, San Francisco, California, USA.
Alzheimers Dement. 2023 Feb;19(2):444-455. doi: 10.1002/alz.12668. Epub 2022 Apr 16.
Relying on magnetic resonance imaging (MRI) for quantification of positron emission tomography (PET) images may limit generalizability of the results. We evaluated several MRI-free approaches for amyloid beta (Aβ) and tau PET quantification relative to MRI-dependent quantification cross-sectionally and longitudinally.
We compared baseline MRI-free and MRI-dependent measurements of Aβ PET ([18F]florbetapir [FBP], N = 1290, [18F]florbetaben [FBB], N = 290) and tau PET ([18F]flortaucipir [FTP], N = 768) images with respect to continuous and dichotomous agreement, effect sizes of Aβ+ impaired versus Aβ- unimpaired groups, and longitudinal standardized uptake value ratio (SUVR) slopes in a subset of individuals.
The best-performing MRI-free approaches had high continuous and dichotomous agreement with MRI-dependent SUVRs for Aβ PET and temporal flortaucipir (R ≥0.95; ± agreement ≥92%) and for Alzheimer's disease-related effect sizes; agreement was slightly lower for entorhinal flortaucipir and longitudinal slopes.
There is no consistent loss of baseline or longitudinal AD-related signal with MRI-free Aβ and tau PET image quantification.
依靠磁共振成像（MRI）对正电子发射断层扫描（PET）图像进行定量可能会限制结果的通用性。我们评估了几种无 MRI 的方法，以横向和纵向比较相对于 MRI 依赖的定量方法对淀粉样蛋白β（Aβ）和 tau PET 的定量。
我们比较了基线无 MRI 和 MRI 依赖的 Aβ PET（[18F]florbetapir [FBP]，N = 1290，[18F]florbetaben [FBB]，N = 290）和 tau PET（[18F]flortaucipir [FTP]，N = 768）图像的连续和二分类一致性、Aβ+损伤组与 Aβ-未损伤组的效应大小，以及在一部分个体中的纵向标准化摄取值比（SUVR）斜率。
无 MRI 的最佳方法在 Aβ PET 和时间 flortaucipir（R ≥0.95；±一致性≥92%）以及与阿尔茨海默病相关的效应大小方面，与 MRI 依赖的 SUVR 具有高度的连续和二分类一致性；对于内嗅皮质 flortaucipir 和纵向斜率，一致性略低。
无 MRI 的 Aβ 和 tau PET 图像定量没有明显的基线或纵向 AD 相关信号丢失。
