Lacey R W, Kruczenyk S C
J Antimicrob Chemother. 1986 Oct;18 Suppl C:207-14. doi: 10.1093/jac/18.supplement_c.207.
The genetic equipment of Staphylococcus aureus is at least as comprehensive as other organisms. Transposons provide the potential for reassortment of genes between plasmids and the chromosome. At least six different mechanisms of gene transfer between cells are documented in vitro. Phage-mediated conjugation is the transfer mechanism most likely to occur between staphylococci in nature. MRSA have evolved from a single clone and are now heterogeneous in properties. Some may show decreased virulence. The origin of new resistant determinants is likely to be other human cultures of Staph. aureus rather than an animal staphylococcal reservoir.
金黄色葡萄球菌的遗传物质至少与其他生物一样全面。转座子为质粒和染色体之间的基因重排提供了可能性。体外已记录到细胞间至少六种不同的基因转移机制。噬菌体介导的接合是自然界中葡萄球菌之间最可能发生的转移机制。耐甲氧西林金黄色葡萄球菌（MRSA）由单一克隆进化而来，现在其特性具有异质性。有些可能表现出毒力下降。新耐药决定因素的起源可能是其他人类金黄色葡萄球菌培养物，而非动物葡萄球菌库。
