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一项在内因性抑郁症患者中比较缓释阿米替林（Saroten Retard）与传统阿米替林片剂（Saroten）并同时测定血清中阿米替林和去甲替林水平的临床试验。

A clinical trial comparing sustained release amitryptyline (Saroten Retard) and conventional amitriptyline tablets (Saroten) in endogenously depressed patients with simultaneous determination of serum levels of amitryptyline and nortriptyline.

作者信息

Liisberg P, Mose H, Amdisen A, Jørgensen A, Petersen H E

出版信息

Acta Psychiatr Scand. 1978 May;57(5):426-35. doi: 10.1111/j.1600-0447.1978.tb06911.x.

DOI:10.1111/j.1600-0447.1978.tb06911.x
PMID:354330
Abstract

The clinical effect of a sustained release preparation of amitriptyline has been compared with that of conventional amitriptyline tablets in a double-blind cross-over study with 24 patients suffering from endogenous depression. The sustained release preparation was given in a single evening dose (9 p.m.) of two thirds the total daily dose of conventional tablets, which was given in a three times-a-day regimen (8 a.m., 12 a.m. and 9 p.m.). Serum concentrations of amitriptyline and its active metabolite, nortriptyline, were determined. No difference was found between the two preparations as regards either clinical effect or side effects. No correlation could be shown between the clinical effects and the serum concentrations of amitriptyline and nortriptyline.

摘要

在一项针对24名内源性抑郁症患者的双盲交叉研究中，对阿米替林缓释制剂与传统阿米替林片剂的临床效果进行了比较。缓释制剂在晚上9点单次给药，剂量为传统片剂每日总剂量的三分之二，传统片剂则采用每日三次给药方案（上午8点、中午12点和晚上9点）。测定了阿米替林及其活性代谢物去甲替林的血清浓度。在临床效果或副作用方面，两种制剂之间未发现差异。未发现临床效果与阿米替林和去甲替林血清浓度之间存在相关性。

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1
A clinical trial comparing sustained release amitryptyline (Saroten Retard) and conventional amitriptyline tablets (Saroten) in endogenously depressed patients with simultaneous determination of serum levels of amitryptyline and nortriptyline.一项在内因性抑郁症患者中比较缓释阿米替林（Saroten Retard）与传统阿米替林片剂（Saroten）并同时测定血清中阿米替林和去甲替林水平的临床试验。
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引用本文的文献

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Measurement of serum drug levels in the assessment of antidepressants.在抗抑郁药评估中血清药物水平的测定。
Br J Clin Pharmacol. 1980 Nov;10(5):411-6. doi: 10.1111/j.1365-2125.1980.tb01781.x.
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