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Clin Cancer Res. 2021 Jun 15;27(12):3351-3359. doi: 10.1158/1078-0432.CCR-20-4443. Epub 2021 Jan 27.
2
Preoperative pembrolizumab combined with chemoradiotherapy for oesophageal squamous cell carcinoma (PALACE-1).术前帕博利珠单抗联合放化疗治疗食管鳞癌（PALACE-1）。
Eur J Cancer. 2021 Feb;144:232-241. doi: 10.1016/j.ejca.2020.11.039. Epub 2020 Dec 26.
3
A More Extensive Lymphadenectomy Enhances Survival After Neoadjuvant Chemoradiotherapy in Locally Advanced Esophageal Adenocarcinoma.新辅助放化疗后广泛淋巴结清扫术可提高局部晚期食管腺癌患者的生存率。
Ann Surg. 2022 Aug 1;276(2):312-317. doi: 10.1097/SLA.0000000000004479. Epub 2020 Nov 17.
4
Clinical Outcome in Patients with Carcinoma of the Esophagogastric Junction Treated with Neoadjuvant Radiochemotherapy or Perioperative Chemotherapy: A Two-Center Retrospective Analysis.新辅助放化疗或围手术期化疗治疗食管胃结合部癌患者的临床结局：一项两中心回顾性分析。
Oncology. 2020;98(10):706-713. doi: 10.1159/000507706. Epub 2020 Jun 9.
5
Preoperative Chemoradiation Versus Chemotherapy in Gastroesophageal Junction Adenocarcinoma.胃食管结合部腺癌的术前放化疗与化疗比较。
Ann Thorac Surg. 2020 Aug;110(2):398-405. doi: 10.1016/j.athoracsur.2020.03.024. Epub 2020 Apr 11.
6
Gastro-oesophageal junction: to FLOT or to CROSS?胃食管交界部：选择FLOT方案还是CROSS方案？
Acta Oncol. 2020 Feb;59(2):233-236. doi: 10.1080/0284186X.2019.1698765. Epub 2019 Dec 9.
7
Esophagogastric junction adenocarcinomas: individualization of resection with special considerations for Siewert type II, and Nishi types EG, E=G and GE cancers.食管胃结合部腺癌：Siewert Ⅱ型及 Nishi 型 EG、E=G 和 GE 癌的个体化切除术
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8
Association between time interval from neoadjuvant chemoradiotherapy to surgery and complete histological tumor response in esophageal and gastroesophageal junction cancer: a national cohort study.新辅助放化疗与手术时间间隔与食管和胃食管交界处癌完全组织学肿瘤反应的关系：一项全国性队列研究。
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基于证据的食管胃交界部肿瘤治疗方法。

Evidence-based approach to the treatment of esophagogastric junction tumors.

作者信息

Schlottmann Francisco, Casas María A, Molena Daniela

机构信息

Department of Surgery, Hospital Alemán of Buenos Aires, Buenos Aires C1118AAT, Argentina.

Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY 10065, United States.

出版信息

World J Clin Oncol. 2022 Mar 24;13(3):159-167. doi: 10.5306/wjco.v13.i3.159.

DOI:10.5306/wjco.v13.i3.159
PMID:35433293
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8966513/
Abstract

The incidence of esophagogastric junction (EGJ) adenocarcinoma is increasing in developed nations due to the rising prevalence of obesity and gastroesophageal reflux disease. Due to the peculiar location in a histological transition zone between the esophagus and the stomach, the management of EGJ tumors is controversial. Two main surgical approaches exist: total gastrectomy with distal esophagectomy or esophagectomy by either transhiatal or transthoracic approach. These operations differ significantly in the extent of lymphadenectomy. In addition, patients with locally advanced disease can receive either preoperative chemoradiation or perioperative chemotherapy. This evidence-based review analyzes current evidence regarding the management of EGJ tumors in order to help defining the best surgical and systemic treatment of these patients.

摘要

在发达国家，由于肥胖症和胃食管反流病患病率的上升，食管胃交界（EGJ）腺癌的发病率正在增加。由于其位于食管和胃之间的组织学过渡区这一特殊位置，EGJ肿瘤的治疗存在争议。主要有两种手术方法：全胃切除术加远端食管切除术，或经裂孔或经胸入路的食管切除术。这些手术在淋巴结清扫范围上有显著差异。此外，局部晚期疾病患者可接受术前放化疗或围手术期化疗。这篇循证综述分析了关于EGJ肿瘤治疗的现有证据，以帮助确定这些患者的最佳手术和全身治疗方案。