Yu Li, Qiu Chen, Chen Rongchang
Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital (Shenzhen People's Hospital), School of Medicine, Southern University of Science and Technology, Shenzhen Institute of Respiratory Diseases, Shenzhen, China.
Ann Transl Med. 2022 Mar;10(6):375. doi: 10.21037/atm-22-800.
Airway smooth muscle cells (ASMCs) are an important component of the airway. Their thickening and proliferation are important in pathological situations, such as airway remodeling in asthma, but their origin remains unclear. Therefore, characterizing molecular markers of ASMCs were sought to identify the source of increased ASMCs in asthmatic airway remodeling.
Articles for this review were derived from a review of the literature related to surface markers and biological properties of ASMCs and smooth muscle cells (SMCs) using PubMed, Google Scholar, and Web of Science.
This review discusses several SMC molecular markers, describes the different developmental stages of SMCs that express different molecular markers, and summarizes several classical SMC molecular markers. However, the establishment of a specific molecular marker detection system for ASMCs still faces great challenges.
Although there is no recognized molecular marker detection system for ASMCs, and the study of the properties and sources of increased ASMCs in asthma airway remodeling is still in a state of exploration, the future is promising. Among the SMC markers described in this review, Myosin heavy chain 11 (MYH11) is a molecular marker for mature SMCs and Transgelin (TAGLN) is an early marker for SMC differentiation, and different molecular markers or combinations of molecular markers can be selected for the identification of the properties and sources of increased ASMCs in asthma airway remodeling according to the differentiation period and research needs.
气道平滑肌细胞（ASMCs）是气道的重要组成部分。它们的增厚和增殖在诸如哮喘气道重塑等病理情况下很重要，但其起源仍不清楚。因此，寻求表征ASMCs的分子标志物以确定哮喘气道重塑中ASMCs增加的来源。
本综述的文章来源于使用PubMed、谷歌学术和科学网对与ASMCs和平滑肌细胞（SMCs）的表面标志物及生物学特性相关的文献进行的综述。
本综述讨论了几种SMC分子标志物，描述了表达不同分子标志物的SMC的不同发育阶段，并总结了几种经典的SMC分子标志物。然而，建立针对ASMCs的特异性分子标志物检测系统仍面临巨大挑战。
尽管目前尚无公认的针对ASMCs的分子标志物检测系统，且对哮喘气道重塑中ASMCs增加的特性和来源的研究仍处于探索阶段，但未来前景广阔。在本综述描述的SMC标志物中，肌球蛋白重链11（MYH11）是成熟SMC的分子标志物，而原肌球蛋白（TAGLN）是SMC分化的早期标志物，可根据分化时期和研究需求选择不同的分子标志物或分子标志物组合来鉴定哮喘气道重塑中ASMCs增加的特性和来源。
