Shugushev Kh Kh, Rozenshtraukh L V, Portnoĭ V F, Dvortsin G F, Iushmanova A V
Kardiologiia. 1986 Nov;26(11):36-40.
Cardiotropic action of antiarrhythmic agents etmozin and etacizin, phenothiazine derivatives, was studied electrophysiologically in 42 mongrel dogs (using isolated heart and intact body models). Etmozin produced no direct effect on sinus node function, whereas etacizin suppressed it in isolated hearts. Etmozin and etacizin significantly affected the atrial, atrioventricular-node and His-Purkinje conduction time, having no basic effect on the duration of respective refractory periods. Therefore, they can be referred to antiarrhythmic agents, group 1, subclass C. The magnitude and pattern of etmozin-and etacizin-induced electrophysiologic changes in the isolated heart and the integrated system are basically similar, an evidence of cardiotropic effects of these drugs. The model of an isolated dog heart perfused by a donor dog's blood can be used for the assessment of cardiotropic effects of drugs in preclinical trials of new antiarrhythmic agents.
在42只杂种犬中（使用离体心脏和完整机体模型），通过电生理学方法研究了抗心律失常药物乙吗噻嗪和乙卡嗪（吩噻嗪衍生物）的心脏作用。乙吗噻嗪对窦房结功能无直接影响，而乙卡嗪在离体心脏中可抑制窦房结功能。乙吗噻嗪和乙卡嗪显著影响心房、房室结和希氏-浦肯野纤维的传导时间，对各自不应期的时长无根本影响。因此，它们可归为第1类C亚类抗心律失常药物。乙吗噻嗪和乙卡嗪在离体心脏和整体系统中引起的电生理变化的幅度和模式基本相似，证明了这些药物的心脏作用。供体犬血液灌注的离体犬心脏模型可用于在新抗心律失常药物的临床前试验中评估药物的心脏作用。
