功能性消化不良症状日记与其他问卷相关，并与功能性消化不良患者的严重程度相关：一项多中心、前瞻性观察研究。

Functional dyspepsia symptom diary is correlated with other questionnaires and associated with severity in patients with functional dyspepsia: a multicenter, prospective observational study.

机构信息

State Key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xi'an, China.

Department of Gastroenterology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, China.

出版信息

J Gastroenterol Hepatol. 2022 Jul;37(7):1298-1306. doi: 10.1111/jgh.15854. Epub 2022 Apr 23.

DOI:10.1111/jgh.15854

PMID:35434810

Abstract

BACKGROUND AND AIM

Functional dyspepsia symptom diary (FDSD) is a newly designed questionnaire of functional dyspepsia (FD). The relationships between FDSD and other FD-related questionnaires and patient-reported severity remain unclear. This study aims to investigate the correlations between FDSD and other questionnaires and to determine the relationships between FDSD and FD severity.

METHODS

Consecutive outpatients with FD were prospectively enrolled in four tertiary hospitals. All patients were evaluated by six FD-related questionnaires, including FDSD, Dyspepsia Symptom Severity Index (DSSI), Gastrointestinal Symptom Rating Scale, Short-Form Nepean Dyspepsia Index, and Hamilton Depression and Anxiety Scale (HAMD and HAMA). The severity of FD was also graded as mild, moderate, and severe by patients themselves. Correlations between different scores were assessed by Spearman correlation coefficient (ρ), and risk factors for patient-reported severity were identified.

RESULTS

For 512 enrolled FD patients, the overall median FDSD score was 19 (2-42). FDSD was well correlated with DSSI (ρ = 0.64) and fairly correlated with the other four scores (ρ = 0.32-0.55) (all P < 0.001). Mild, moderate, and severe FD were reported by 18.5%, 55.9%, and 25.6% of patients, respectively. There were seven factors associated with the severe FD, including education level, duration, and subtypes of FD, prior treatment, FDSD, HAMD, and HAMA scores (all P < 0.10). FDSD ≥ 20 (odds ratio [OR] 3.3, 95% confidence interval [CI]: 2.0-5.2, P < 0.001) and HAMD ≥ 13 (OR 2.9, 95% CI: 1.8-4.6, P < 0.001) were independently associated with patient-reported severe FD.

CONCLUSIONS

This study firstly revealed that the newly developed FDSD correlated with other FD-related questionnaires. FDSD ≥ 20 and HAMD ≥ 13 were independently associated with severe FD reported by patients (clinicaltrials.gov number: NCT04953975).

摘要

背景与目的

功能性消化不良症状日记（FDSD）是一种新设计的功能性消化不良（FD）问卷。FDSD 与其他 FD 相关问卷和患者报告的严重程度之间的关系尚不清楚。本研究旨在探讨 FDSD 与其他问卷之间的相关性，并确定 FDSD 与 FD 严重程度之间的关系。

方法

连续纳入四家三级医院的 FD 门诊患者。所有患者均接受 6 种 FD 相关问卷评估，包括 FDSD、消化不良症状严重程度指数（DSSI）、胃肠道症状评分量表、短版 Nepean 消化不良指数和汉密尔顿抑郁和焦虑量表（HAMD 和 HAMA）。患者还自行对 FD 严重程度进行分级，分为轻度、中度和重度。采用 Spearman 相关系数（ρ）评估不同评分之间的相关性，并确定患者报告严重程度的危险因素。

结果

共纳入 512 例 FD 患者，总体 FDSD 评分中位数为 19（2-42）。FDSD 与 DSSI 相关性较好（ρ=0.64），与其他四个评分相关性中等（ρ=0.32-0.55）（均 P<0.001）。18.5%、55.9%和 25.6%的患者分别报告为轻度、中度和重度 FD。与重度 FD 相关的因素有 7 个，包括教育程度、病程和 FD 亚型、既往治疗、FDSD、HAMD 和 HAMA 评分（均 P<0.10）。FDSD≥20（比值比[OR]3.3，95%置信区间[CI]：2.0-5.2，P<0.001）和 HAMD≥13（OR 2.9，95% CI：1.8-4.6，P<0.001）与患者报告的重度 FD 独立相关。