Center for Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China.
Center for Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China; University of Chinese Academy of Sciences, Beijing 100049, China.
J Genet Genomics. 2022 Jun;49(6):519-522. doi: 10.1016/j.jgg.2022.04.001. Epub 2022 Apr 15.
Coat protein complex II (COPII)-coated vesicles are responsible for transporting the cargoes from the endoplasmic reticulum (ER) to different destinations. cTAGE5/MEA6 is essential for the development and function of different organs. It regulates the assembly of COPII carrier and cargo trafficking through direct or indirect interaction with COPII components. cTAGE5/MEA6 mainly coordinates with another scaffold protein, TANGO1, to play essential roles in the trafficking and secretion of both large and small cargoes in multiple organs. In this viewpoint, we would like to discuss the molecular mechanisms underlying cTAGE5/MEA6-mediated cargo transport and biological functions.
外衣蛋白复合物 II（COPII）-被囊泡负责将货物从内质网（ER）运输到不同的目的地。cTAGE5/MEA6 对于不同器官的发育和功能至关重要。它通过直接或间接与 COPII 成分相互作用来调节 COPII 载体的组装和货物运输。cTAGE5/MEA6 主要与另一个支架蛋白 TANGO1 协调，在多个器官中大、小货物的运输和分泌中发挥重要作用。在本观点中，我们将讨论 cTAGE5/MEA6 介导的货物运输和生物学功能的分子机制。
