平均血小板体积及平均血小板体积/血小板计数比值是早产儿迟发性败血症的预测指标：一项病例对照研究。

Mean Platelet Volume and Mean Platelet Volume/Platelet Count Ratio Are Predictors of Late-Onset Sepsis in Preterm Infants: A Case-Control Study.

作者信息

Guney Varal Ipek, Dogan Pelin, Acar Celik Ezgi, Güler Kazancı Elif

机构信息

Department of Pediatrics, Division of Neonatology, University of Health Sciences Bursa Yuksek Ihtisas Teaching Hospital, Bursa, Turkey.

Department of Pediatrics, University of Health Sciences Bursa Yuksek Ihtisas Teaching Hospital, Bursa, Turkey.

出版信息

Fetal Pediatr Pathol. 2023 Feb;42(1):44-54. doi: 10.1080/15513815.2022.2064574. Epub 2022 Apr 19.

DOI:10.1080/15513815.2022.2064574

PMID:35438038

Abstract

Our aim was to assess mean platelet volume (MPV) and mean platelet volume to platelet count ratio (MPR) in the setting of late-onset sepsis (LOS) and their association with the type of bacteria causing LOS. The MPV and MPR levels were obtained at the onset of LOS and then assessed in intra/inter group analyses in preterm infants. Overall, 136 preterm infants were enrolled. The MPV and MPR levels were higher during a LOS event ( < 0.001). A MPV cutoff of >9.2 was related with a sensitivity of 63% and a specificity of 73% for predicting LOS ( < 0.001). A MPR cutoff of >0.15 was related with a sensitivity of 88% and a specificity of 63% for predicting gram negative LOS ( < 0.001). Elevated MPV values and MPR ratios may be helpful in assessing LOS.

摘要

我们的目的是评估晚发性败血症（LOS）情况下的平均血小板体积（MPV）和平均血小板体积与血小板计数比值（MPR），以及它们与导致LOS的细菌类型之间的关联。在LOS发作时获取MPV和MPR水平，然后在早产儿的组内/组间分析中进行评估。总体而言，共纳入了136名早产儿。在LOS事件期间，MPV和MPR水平较高（P＜0.001）。MPV临界值＞9.2时，预测LOS的敏感性为63%，特异性为73%（P＜0.001）。MPR临界值＞0.15时，预测革兰氏阴性菌LOS的敏感性为88%，特异性为63%（P＜0.001）。升高的MPV值和MPR比值可能有助于评估LOS。