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[电离辐射暴露早期大鼠脑灰质中钙、磷脂依赖性蛋白激酶的分离及特性]

[Isolation and properties of the Ca2+, phospholipid-dependent protein kinase from the substantia grisea of the rat brain in the early stage of exposure to ionizing radiation].

作者信息

Ostapchenko L I, Protas A F, Vasil'ev A N, Kucherenko N E

出版信息

Radiobiologiia. 1986 Nov-Dec;26(6):761-5.

PMID:3544012
Abstract

Ca2+, phospholipid-dependent proteinkinase was isolated from intact and exposed (1 h following whole body X-irradiation with a dose of 0.21 C/kg) gray substance of rat brain, and the dependence of this enzyme on pH and temperature, and substrate specificity were studied. Changes were shown to occur in some Ca2+, phospholipid-dependent proteinkinase properties under the effect of X-radiation while the substrate specificity remained unchanged.

摘要

从完整的和经暴露的(全身接受剂量为0.21 C/kg的X射线照射1小时后的)大鼠脑灰质中分离出钙、磷脂依赖性蛋白激酶,并研究了该酶对pH和温度的依赖性以及底物特异性。结果表明,在X射线照射的影响下,某些钙、磷脂依赖性蛋白激酶的性质发生了变化,而底物特异性保持不变。

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