Department of Pharmaceutics, School of Pharmacy & Technology Management, SVKM\'S NMIMS Deemed-to-be University, Shirpur 425405, Maharashtra, India.
Curr Drug Res Rev. 2022;14(3):171-187. doi: 10.2174/2589977514666220418085658.
Lung cancer is the second leading cancer with a high rate of mortality. It can be treated using different intervention techniques such as chemotherapy, radiation therapy, surgical removal, and photodynamic therapy. All of these interventions lack specificity, implying that it harms the normal cells adjacent to the infected ones. Nanotechnology provides a promising solution that increases the bioavailability of anticancer drugs at the tumor site with reduced toxicity and improved therapeutic efficacy. Nanotechnology also improves the way lung cancer is diagnosed and treated. Various nanocarriers like liposomes, polymeric nanoparticles, magnetic nanoparticles, and different theranostic approaches are already approved for medical use, while various are under clinical and preclinical stages. This review article covers the details about lung cancer, types of overexpressed receptors, and cutting-edge nanocarriers used for treating lung cancer at its specific target.
肺癌是第二大常见癌症，死亡率较高。它可以通过不同的干预技术进行治疗，如化疗、放射治疗、手术切除和光动力疗法。所有这些干预措施都缺乏特异性，这意味着它们会损害感染细胞周围的正常细胞。纳米技术提供了一个有前途的解决方案，它可以增加肿瘤部位抗癌药物的生物利用度，同时降低毒性和提高治疗效果。纳米技术还改善了肺癌的诊断和治疗方式。各种纳米载体，如脂质体、聚合物纳米颗粒、磁性纳米颗粒和不同的治疗方法已经被批准用于医疗用途，而各种处于临床和临床前阶段。这篇综述文章涵盖了肺癌的详细信息、过表达受体的类型，以及用于治疗特定靶点肺癌的最先进的纳米载体。
