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采用氮化硅椎间融合器的经椎间孔腰椎椎间融合术显示出早期影像学融合。

Transforaminal lumbar interbody fusion with a silicon nitride cage demonstrates early radiographic fusion.

作者信息

Gray Mitchell T, Davis Kyle P, McEntire Bryan J, Bal B Sonny, Smith Micah W

机构信息

Indiana University School of Medicine, Indianapolis, IN, USA.

SINTX Technologies Corporation, Salt Lake City, UT, USA.

出版信息

J Spine Surg. 2022 Mar;8(1):29-43. doi: 10.21037/jss-21-115.

Abstract

BACKGROUND

Degeneration of the lumbar spine is common in aging adults and reflects a significant morbidity burden in this population. In selected patients that prove unresponsive to non-surgical treatment, posterior lumbar fusion (PLF) surgery, with or without adjunctive transforaminal lumbar interbody fusion (TLIF) can relieve pain and improve function. We describe here the radiographic fusion rates for PLF versus TLIF, using an intervertebral spinal cage made of silicon nitride ceramic (chemical formula SiN).

METHODS

This retrospective cohort analysis enrolled 99 patients from August 2013 to January 2017; 17 had undergone PLF at 24 levels, while 82 had undergone TLIF at 104 levels. All operations were performed by a single surgeon at one institution. Radiographic and clinical outcomes were compared between PLF and TLIF at 2 and 6 weeks and then at 3, 6, 12, and 24 months.

RESULTS

TLIF patients fused at higher rates compared to PLF at the 3-month (38.5% 8.3%, P=0.006), 6-month (78.7% 35.0%, P<0.001) and 12-month time periods (97.9% 81.3%, P=0.018), with no difference at 24 months (100% 94.4%, P=0.102). Index level segmental motion was significantly less and intervertebral disc height was improved in TLIF over PLF at all follow up intervals. Foraminal height was only greater in early follow up periods (2 weeks, 6 weeks and 3 months). TLIF patients experienced lover rates of PI-LL mismatch which was maintained across long term follow-up. Pelvic tilt was lower following TLIF compared to PLF, with no differences in complication rates between study groups.

CONCLUSIONS

Our retrospective series demonstrated that TLIF performed with silicon nitride interbody cages led to earlier radiographic fusion, greater restoration of disc and foraminal height, increased segmental rigidity and improved sagittal alignment when compared to PLF alone.

摘要

背景

腰椎退变在老年人中很常见,且在该人群中反映出显著的发病负担。在经选择对非手术治疗无反应的患者中,后路腰椎融合术(PLF),无论是否辅助经椎间孔腰椎椎间融合术(TLIF),都可缓解疼痛并改善功能。我们在此描述使用由氮化硅陶瓷(化学式SiN)制成的椎间融合器的PLF与TLIF的影像学融合率。

方法

这项回顾性队列分析纳入了2013年8月至2017年1月的99例患者;17例接受了24节段的PLF,而82例接受了104节段的TLIF。所有手术均由同一机构的一名外科医生进行。在2周和6周以及之后的3、6、12和24个月对PLF和TLIF的影像学和临床结果进行比较。

结果

与PLF相比,TLIF患者在3个月(38.5% 对8.3%,P = 0.006)、6个月(78.7% 对35.0%,P < 0.001)和12个月时的融合率更高(97.9% 对81.3%,P = 0.018),在24个月时无差异(100% 对94.4%,P = 0.102)。在所有随访间隔中,TLIF组的索引节段运动明显更小,椎间盘高度较PLF组有所改善。椎间孔高度仅在早期随访期(2周、6周和3个月)更大。TLIF患者出现PI-LL不匹配的发生率较低,且在长期随访中保持不变。与PLF相比,TLIF术后骨盆倾斜度更低,研究组间并发症发生率无差异。

结论

我们的回顾性系列研究表明,与单纯PLF相比,使用氮化硅椎间融合器进行的TLIF可实现更早的影像学融合、更大程度地恢复椎间盘和椎间孔高度、增加节段刚性并改善矢状面排列。

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