• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

减轻新冠长期症状中的疲劳相关症状:一项淋巴引流干预的初步报告

Reducing fatigue-related symptoms in Long COVID-19: a preliminary report of a lymphatic drainage intervention.

作者信息

Heald Adrian, Perrin Raymond, Walther Andreas, Stedman Mike, Hann Mark, Mukherjee Annice, Riste Lisa

机构信息

The School of Health Sciences, Faculty of Biology Medicine and Health, The University of Manchester, Manchester.

Department of Endocrinology and Diabetes, Salford Royal Hospital, Salford, UK.

出版信息

Cardiovasc Endocrinol Metab. 2022 Apr 12;11(2):e0261. doi: 10.1097/XCE.0000000000000261. eCollection 2022 Jun.

DOI:10.1097/XCE.0000000000000261
PMID:35441129
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9010124/
Abstract

UNLABELLED

In the early days of the first global wave of the COVID-19 pandemic, the potential for a postviral syndrome to manifest following COVID-19 infection was first recognized. Here, we present an analysis of a case series of the first 20 patients' data collected in clinical practice to evaluate the potential of a possible alternative treatment for Long COVID.

METHODS

Face-to-face treatment sessions with Perrin technique practitioners occurred weekly involving effleurage/other manual articulatory techniques. The individuals being treated also undertook daily self-massage along with gentle mobility exercises. Patients recorded symptom severity using the self-report 54-item profile of fatigue-related states (PFRS) before and after treatment.

RESULTS

The mean age of male patients was 41.8 years (range, 29-53 years), and for female patients, 39.3 years (range, 28-50 years). None of the participants had a prior diagnosis of chronic fatigue syndrome, and all were new attendees to the clinics at the time of initial assessment. The average number of treatment sessions was 9.7 in men and 9.4 in women. The reduction in PFRS scores was 45% in men and 52% in women. The highest subscale scores on average were for fatigue, with the lowest for somatic symptoms. All subscale scores showed, on average, a similar reduction of approximately 50% postintervention, with the reduction in score relating to a decrease in the severity of symptoms.

CONCLUSION

Our findings suggest that a specific manual lymphatic drainage intervention may help to reduce fatigue symptoms related to Long COVID. Perhaps preventing acute symptoms through early intervention.

摘要

未标注

在新冠疫情全球第一波流行的早期,人们首次认识到新冠病毒感染后可能出现病毒感染后综合征。在此,我们对临床实践中收集的首批20例患者的数据进行了病例系列分析,以评估针对新冠长期症状可能的替代治疗方法的潜力。

方法

与采用佩兰技术的治疗师进行每周一次的面对面治疗,包括轻抚法/其他手动关节技术。接受治疗的个体还每天进行自我按摩以及轻柔的活动练习。患者在治疗前后使用自我报告的54项疲劳相关状态量表(PFRS)记录症状严重程度。

结果

男性患者的平均年龄为41.8岁(范围29 - 53岁),女性患者为39.3岁(范围28 - 50岁)。所有参与者之前均未被诊断为慢性疲劳综合征,且在初次评估时均为诊所新就诊者。男性的平均治疗次数为9.7次,女性为9.4次。男性PFRS评分降低了45%,女性降低了52%。平均而言,最高的子量表分数是疲劳方面,最低的是躯体症状方面。所有子量表分数平均在干预后均有类似的约50%的降低,分数降低与症状严重程度的减轻相关。

结论

我们的研究结果表明,一种特定的手动淋巴引流干预可能有助于减轻与新冠长期症状相关的疲劳症状。或许通过早期干预可预防急性症状。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c598/9010124/fb1aad850ce0/xce-11-e0261-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c598/9010124/fb1aad850ce0/xce-11-e0261-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c598/9010124/fb1aad850ce0/xce-11-e0261-g001.jpg

相似文献

1
Reducing fatigue-related symptoms in Long COVID-19: a preliminary report of a lymphatic drainage intervention.减轻新冠长期症状中的疲劳相关症状:一项淋巴引流干预的初步报告
Cardiovasc Endocrinol Metab. 2022 Apr 12;11(2):e0261. doi: 10.1097/XCE.0000000000000261. eCollection 2022 Jun.
2
Folic acid supplementation and malaria susceptibility and severity among people taking antifolate antimalarial drugs in endemic areas.在流行地区,服用抗叶酸抗疟药物的人群中,叶酸补充剂与疟疾易感性和严重程度的关系。
Cochrane Database Syst Rev. 2022 Feb 1;2(2022):CD014217. doi: 10.1002/14651858.CD014217.
3
Telephone interventions for symptom management in adults with cancer.针对成年癌症患者症状管理的电话干预措施。
Cochrane Database Syst Rev. 2020 Jun 2;6(6):CD007568. doi: 10.1002/14651858.CD007568.pub2.
4
Virtualized clinical studies to assess the natural history and impact of gut microbiome modulation in non-hospitalized patients with mild to moderate COVID-19 a randomized, open-label, prospective study with a parallel group study evaluating the physiologic effects of KB109 on gut microbiota structure and function: a structured summary of a study protocol for a randomized controlled study.用于评估非住院轻中度 COVID-19 患者肠道微生物组调节的自然史和影响的虚拟化临床研究:一项随机、开放标签、前瞻性研究,平行组研究评估 KB109 对肠道微生物组结构和功能的生理影响:一项随机对照研究方案的结构化总结。
Trials. 2021 Apr 2;22(1):245. doi: 10.1186/s13063-021-05157-0.
5
Effects of Massage Therapy on Multiple Sclerosis: a Case Report.按摩疗法对多发性硬化症的影响:一例报告
Int J Ther Massage Bodywork. 2020 Dec 1;13(4):35-41. eCollection 2020 Dec.
6
Severe Fatigue in Long COVID: Web-Based Quantitative Follow-up Study in Members of Online Long COVID Support Groups.长新冠严重疲劳:在线长新冠支持团体成员的基于网络的定量随访研究。
J Med Internet Res. 2021 Sep 21;23(9):e30274. doi: 10.2196/30274.
7
Manual Lymph Drainage for Post-COVID-19 Related Cough, Breathlessness, and Fatigue; Two Case Reports.针对新冠后相关咳嗽、呼吸急促和疲劳的手法淋巴引流;两例病例报告
Healthcare (Basel). 2023 Dec 1;11(23):3085. doi: 10.3390/healthcare11233085.
8
Impact of fatigue as the primary determinant of functional limitations among patients with post-COVID-19 syndrome: a cross-sectional observational study.疲劳对新冠后综合征患者功能障碍的影响:一项横断面观察性研究。
BMJ Open. 2023 Jun 7;13(6):e069217. doi: 10.1136/bmjopen-2022-069217.
9
Effect of effleurage massage therapy on sleep disturbance, fatigue, pain, and anxiety in patients with multiple sclerosis: A quasi-experimental study.抚触按摩疗法对多发性硬化症患者睡眠障碍、疲劳、疼痛和焦虑的影响:一项准实验研究。
Appl Nurs Res. 2023 Oct;73:151719. doi: 10.1016/j.apnr.2023.151719. Epub 2023 Jul 31.
10
Persistent effects of COVID-19 in patients hospitalized during the first wave of the pandemic: The impact of persistent fatigue on quality of life in a cross-sectional study.新冠疫情第一波期间住院患者中新冠病毒病的持续影响:一项横断面研究中持续疲劳对生活质量的影响
J Med Virol. 2023 Feb;95(2):e28491. doi: 10.1002/jmv.28491.

引用本文的文献

1
Acute Effects of Osteopathic Treatment in Long COVID-19 Patients with Fatigue Symptoms: A Randomized, Controlled Trial.整骨疗法对伴有疲劳症状的新冠长期症状患者的急性影响:一项随机对照试验。
J Clin Med. 2025 Aug 27;14(17):6066. doi: 10.3390/jcm14176066.
2
Rehabilitation interventions and outcomes for post-COVID condition: a scoping review.新冠后状况的康复干预措施及结果:一项范围综述
BMJ Public Health. 2025 Feb 26;3(1):e001827. doi: 10.1136/bmjph-2024-001827. eCollection 2025 Jan.
3
Defining and measuring long COVID fatigue: a scoping review.

本文引用的文献

1
Excessive eating and weight gain:A rare post-acute COVID-19 syndrome.过度进食和体重增加:一种罕见的新冠后急性综合征。
Diabetes Metab Syndr. 2021 Sep-Oct;15(5):102252. doi: 10.1016/j.dsx.2021.102252. Epub 2021 Aug 21.
2
6-month consequences of COVID-19 in patients discharged from hospital: a cohort study.新冠肺炎出院患者 6 个月的后果:一项队列研究。
Lancet. 2021 Jan 16;397(10270):220-232. doi: 10.1016/S0140-6736(20)32656-8. Epub 2021 Jan 8.
3
COVID-19 and chronic fatigue syndrome: Is the worst yet to come?COVID-19 与慢性疲劳综合征:最糟糕的情况会到来吗?
定义和测量新冠后疲劳:一项范围综述
BMJ Open. 2024 Dec 11;14(12):e088530. doi: 10.1136/bmjopen-2024-088530.
4
Cardiopulmonary and metabolic responses during a 2-day CPET in myalgic encephalomyelitis/chronic fatigue syndrome: translating reduced oxygen consumption to impairment status to treatment considerations.在肌痛性脑脊髓炎/慢性疲劳综合征的 2 天 CPET 期间的心肺和代谢反应:将耗氧量减少转化为功能障碍状态以考虑治疗。
J Transl Med. 2024 Jul 5;22(1):627. doi: 10.1186/s12967-024-05410-5.
5
The Multisystem effects of Long COVID Syndrome and Potential Benefits of Massage Therapy in Long COVID Care.长新冠综合征的多系统影响及按摩疗法在长新冠护理中的潜在益处。
Int J Ther Massage Bodywork. 2024 Mar 14;17(1):19-42. doi: 10.3822/ijtmb.v17i1.767. eCollection 2024 Mar.
6
Manual Lymph Drainage for Post-COVID-19 Related Cough, Breathlessness, and Fatigue; Two Case Reports.针对新冠后相关咳嗽、呼吸急促和疲劳的手法淋巴引流;两例病例报告
Healthcare (Basel). 2023 Dec 1;11(23):3085. doi: 10.3390/healthcare11233085.
7
Long COVID: Complications, Underlying Mechanisms, and Treatment Strategies.长期新冠:并发症、潜在机制及治疗策略
Arch Microbiol Immunol. 2023;7(2):36-61. Epub 2023 May 9.
8
Clinical effectiveness of rehabilitation in ambulatory care for patients with persisting symptoms after COVID-19: a systematic review.COVID-19 后持续症状患者门诊康复治疗的临床效果:系统评价。
BMC Infect Dis. 2023 Jun 21;23(1):419. doi: 10.1186/s12879-023-08374-x.
Med Hypotheses. 2021 Jan;146:110469. doi: 10.1016/j.mehy.2020.110469. Epub 2021 Jan 2.
4
The S1 protein of SARS-CoV-2 crosses the blood-brain barrier in mice.SARS-CoV-2 的 S1 蛋白可穿越血脑屏障进入小鼠脑内。
Nat Neurosci. 2021 Mar;24(3):368-378. doi: 10.1038/s41593-020-00771-8. Epub 2020 Dec 16.
5
Olfactory transmucosal SARS-CoV-2 invasion as a port of central nervous system entry in individuals with COVID-19.COVID-19 患者中嗅黏膜 SARS-CoV-2 入侵作为中枢神经系统进入的途径。
Nat Neurosci. 2021 Feb;24(2):168-175. doi: 10.1038/s41593-020-00758-5. Epub 2020 Nov 30.
6
Long COVID and chronic COVID syndromes.长期新冠和慢性新冠综合征。
J Med Virol. 2021 Mar;93(3):1242-1243. doi: 10.1002/jmv.26587. Epub 2020 Oct 30.
7
Into the looking glass: Post-viral syndrome post COVID-19.透过镜子:新冠病毒感染后的病毒后综合征
Med Hypotheses. 2020 Nov;144:110055. doi: 10.1016/j.mehy.2020.110055. Epub 2020 Jun 27.
8
The efficacy of muscle energy techniques in symptomatic and asymptomatic subjects: a systematic review.肌肉能量技术在有症状和无症状受试者中的疗效:一项系统综述。
Chiropr Man Therap. 2019 Aug 27;27:35. doi: 10.1186/s12998-019-0258-7. eCollection 2019.
9
The Impact of Spinal Manipulation on Migraine Pain and Disability: A Systematic Review and Meta-Analysis.脊柱推拿对偏头痛疼痛和残疾的影响:系统评价和荟萃分析。
Headache. 2019 Apr;59(4):532-542. doi: 10.1111/head.13501. Epub 2019 Mar 14.
10
Handling missing items in the Hospital Anxiety and Depression Scale (HADS): a simulation study.《医院焦虑抑郁量表(HADS)中缺失项的处理:一项模拟研究》
BMC Res Notes. 2016 Oct 22;9(1):479. doi: 10.1186/s13104-016-2284-z.