用于易于聚集肽的微波辅助合成中的CSY保护基团。
The CSY-protecting group in the microwave-assisted synthesis of aggregation-prone peptides.
作者信息
Pham Truc Lam, Zilke Jennifer, Müller Christine Charlotte, Thomas Franziska
机构信息
Institute of Organic Chemistry, Heidelberg University, Im Neuenheimer Feld 270 69120 Heidelberg Germany
Centre for Advanced Materials, Heidelberg University, Im Neuenheimer Feld 225 69120 Heidelberg Germany.
出版信息
RSC Chem Biol. 2022 Feb 18;3(4):426-430. doi: 10.1039/d1cb00252j. eCollection 2022 Apr 6.
This report describes the application of cyanosulfurylide (CSY)-protected aspartatic acid building blocks in microwave-assisted synthesis of aggregation-prone protein domains. We present a synthesis of Fmoc-Asp(CSY)-OH on a multigram scale, as well as procedures for the microwave-assisted synthesis of CSY-protected peptides, and CSY cleavage in partially folded or aggregation-prone peptides.
本报告描述了氰基硫叶立德（CSY）保护的天冬氨酸构建块在微波辅助合成易聚集蛋白结构域中的应用。我们展示了多克规模的Fmoc-Asp(CSY)-OH的合成，以及微波辅助合成CSY保护肽和在部分折叠或易聚集肽中进行CSY切割的方法。
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