Intermediary metabolite profiles during euglycemic glucose-insulin clamp: effects of ethanol.

We evaluated the effects of different doses of i.v. alcohol on tissue insulin sensitivity, by means of insulin-glucose clamp technique, in 10 young healthy men. The most important intermediary metabolites were assayed. Insulin-dependent glucose disposal was impaired at different levels of alcoholemia, probably through an impairment of the glycolytic pathway. Exogenous insulin administration does not restore the more reduced redox state caused by alcohol oxidation. Alcohol does not interfere with the antiketogenic and antilipolytic insulin effects.