Khalid A M A M, Suliman A M, Abdallah E I, Abakar M A A, Elbasheir M M, Muddathir A M, Aldakheel F M, Bin Shaya A S, Alfahed A, Alharthi N S, Aloraini G S, Alenazi M M, Waggiallah H A
Department of Hematology and Blood Transfusion, Department of Microbiology, Department of Parasitology and Medical Entomology, Faculty of Medical Laboratory Science, Alzaeim Alazhari University, Khartoum, Sudan.
Eur Rev Med Pharmacol Sci. 2022 Apr;26(7):2579-2585. doi: 10.26355/eurrev_202204_28495.
The aim of the study was to detect the effect of COVID-19 on lymphocyte and platelet parameters among Sudanese patients admitted to Intensive Care unit (ICU) and emergency (ER).
This cross-sectional study was carried out on a total of 787 Sudanese individuals (487 confirmed COVID-19 cases and 300 apparently healthy individuals as controls, in duration between April 2020 to December 2020). Platelets (PLTs) and platelet indices, mean platelet volume (MPV), platelet distribution width (PDW), plateletcrit (PCT) and platelet larger cell ratio (PLCR) were investigated as part of the complete blood count (CBC) for the case and control group. Also, the neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) were calculated, and the results were statistically analyzed by SPSS version 21.
The severity of the disease was also affected by the patient's age: 262 COVID-19 cases admitted to ICU were over 50 years old, compared to only four patients in the mild group. Regarding hematological parameters, the absolute lymphocyte count, PLTs, MPV, PDW, and P-LCR were significantly different between cases and control groups (p-values = 0.000, 0.002, 0.000, 0.000, and 0.000, respectively). PLR and NLR levels were found to be significantly higher as disease severity increased; p-values = 0.000 and 0.000, respectively. The study also demonstrated that lymphopenia was associated with severe COVID-19 infection (in 93% of ICU patients, 59.9% of ER, and 9% of the mild group), while thrombocytopenia was detected only among 30.8% of ICU patients.
Lymphopenia and thrombocytopenia are associated with severe COVID-19 infection. NLR and PLR were markedly increased with COVID-19.
本研究旨在检测新型冠状病毒肺炎（COVID-19）对入住重症监护病房（ICU）和急诊科（ER）的苏丹患者淋巴细胞和血小板参数的影响。
本横断面研究共纳入787名苏丹人（487例确诊的COVID-19病例和300名明显健康的个体作为对照，时间跨度为2020年4月至2020年12月）。作为病例组和对照组全血细胞计数（CBC）的一部分，对血小板（PLTs）及其指标，即平均血小板体积（MPV）、血小板分布宽度（PDW）、血小板压积（PCT）和血小板大细胞比率（PLCR）进行了研究。此外，计算了中性粒细胞淋巴细胞比率（NLR）和血小板淋巴细胞比率（PLR），并使用SPSS 21版对结果进行了统计分析。
疾病的严重程度还受患者年龄影响：262例入住ICU的COVID-19病例年龄超过50岁，而轻症组仅有4例患者。关于血液学参数，病例组和对照组之间的绝对淋巴细胞计数、PLTs、MPV、PDW和P-LCR存在显著差异（p值分别为0.000、0.002、0.000、0.000和0.000）。发现随着疾病严重程度增加，PLR和NLR水平显著升高；p值分别为0.000和0.000。该研究还表明，淋巴细胞减少与严重的COVID-19感染相关（93%的ICU患者、59.9%的ER患者和9%的轻症组患者），而血小板减少仅在30.8%的ICU患者中检测到。
淋巴细胞减少和血小板减少与严重的COVID-19感染相关。COVID-19患者的NLR和PLR明显升高。
